中国病理生理杂志2026，Vol.42Issue(5)：1018-1024,7.DOI:10.3969/j.issn.1000-4718.2026.05.020
铁/铜依赖性细胞死亡的交互调控模式与病理机制
Interactive regulatory patterns and pathological mechanisms of iron/cop-per-dependent cell death
摘要
Abstract
As essential micronutrients with strong redox activity,the homeostasis of iron and copper critically influences cell fate.Ferroptosis is a regulated,non-apoptotic form of cell death characterized by iron-dependent lipid per-oxidation,mainly controlled by iron metabolism,lipid biosynthesis,and antioxidant defense systems.In contrast,cupro-ptosis depends on pathological accumulation of copper ions,which induces aggregation of mitochondrial lipoylated proteins and loss of iron-sulfur(Fe-S)cluster-containing enzymes,tightly linking its occurrence to tricarboxylic acid(TCA)cycle function.Although the initiating triggers,effector molecules,and mechanistic pathways of ferroptosis and cuproptosis are inherently distinct,increasing evidence indicates that they are not independent regulatory systems but form a complex in-tracellular crosstalk network.Accordingly,this review summarizes the core regulatory mechanisms of ferroptosis and cu-proptosis,emphasizes their interactions in key biological processes,and describes how these two cell death modes inter-sect in regulating mitochondrial function,autophagy,oxidative stress responses,and glutathione(GSH)metabolism un-der physiological and pathological conditions.关键词
铁死亡/铜死亡/线粒体/氧化应激Key words
ferroptosis/cuproptosis/mitochondrion/oxidative stress分类
医药卫生引用本文复制引用
杜书琴,林洪盛,戴晶,李嘉滢..铁/铜依赖性细胞死亡的交互调控模式与病理机制[J].中国病理生理杂志,2026,42(5):1018-1024,7.基金项目
新疆维吾尔自治区"2+5"重点人才计划-"天山英才"培养计划(No.2024TSYCJC0057 （）
No.2023TSYCJC0062) （）
新疆维吾尔自治区自然科学基金资助项目(No.2025D01B151 （）
No.2023D01B27) （）
