中国动脉硬化杂志2026，Vol.34Issue(4)：359-366,8.DOI:10.20039/j.cnki.1007-3949.2026.04.010
GATA4促进细胞衰老及相关疾病进展
GATA4 promotes cellular senescence and the progression of related diseases
摘要
Abstract
GATA4,a key member of the GATA zinc finger family,plays a crucial role in cellular senescence.GATA4 affects chronic inflammation,oxidative stress,cell cycle progression,apoptosis,and metabolic alterations to facili-tate the development of cellular senescence.GATA4 promotes vascular endothelial cell senescence and drives the devel-opment of coronary atherosclerotic heart disease(CAD);GATA4 facilitates pathological myocardial tissue remodeling,hy-pertrophy,and the progression of heart failure;GATA4 accelerates lens epithelial cell senescence,hastening the onset and progression of age-related cataract(ARC).Conclusively,GATA4 plays an important role in cellular senescence and re-lated cardiovascular diseases,and can serve as a potential target for the diagnosis and treatment of age-related diseases.关键词
GATA4/细胞衰老/衰老相关疾病Key words
GATA4/cellular senescence/aging-related diseases分类
医药卫生引用本文复制引用
张绍香,周乐,李慧娟,吕运成..GATA4促进细胞衰老及相关疾病进展[J].中国动脉硬化杂志,2026,34(4):359-366,8.基金项目
广西壮族自治区自然科学基金项目(2024JJA141030) （2024JJA141030）
国家自然科学基金项目(82160098) （82160098）
广西临床重点专科项目(桂卫医发[2023]26号) （桂卫医发[2023]26号）
