中国防痨杂志2026，Vol.48Issue(6)：821-829,9.DOI:10.19982/j.issn.1000-6621.20250454
新疆维吾尔自治区南疆地区肺结核患者治疗相关心理负担影响因素及其作用路径分析
Analysis of influencing factors and pathways on psychological burden associated with pulmonary tuberculosis treatment in Southern Xinjiang Region of the Xinjiang Uygur Autonomous Region
摘要
Abstract
Objective:To investigate the factors influencing treatment-related psychological burden among tuberculosis patients in Southern Xinjiang Uygur Autonomous Region and their underlying pathways.Methods:From January 2024 to July 2025,a stratified clustered random sampling method was used to select 1483 patients with pulmonary tuberculosis who were registered in the Tuberculosis Information Management System and completed treatment in 8 counties/districts of 4 prefectures in southern Xinjiang for questionnaire survey.Multilevel model and structural equation model were constructed to explore the influencing factors of treatment-related psychological burden and their pathways,and to test the mediating effect of patients'medication compliance.Results:A total of 1483 patients were included,with 470(31.7％)exhibiting high psychological burden.Multilevel modeling revealed that lower educational attainment(OR=1.675,95％CI:1.293-2.169),poor disease cognition(OR=2.340,95％CI:1.733-3.159),poor medication adherence(OR=2.370,95％CI:1.639-3.426),family dysfunction(OR=1.695,95％CI:1.157-3.003),insufficient family support(OR=2.329,95％CI:1.771-3.062),and dissatisfaction with treatment(OR=3.109,95％CI:2.229-4.336)were independent risk factors for psychological burden.Structural equation modeling results indicated that family functioning(β=0.120)and satisfaction(β=0.367)exerted direct positive effects on psychological burden,while family support demonstrated a direct negative effect(β=-0.097).Medication adherence fully mediated the effects of family functioning and family support on psychological burden.Their direct effects were-0.096 and 0.117,respectively,while indirect effects were-0.001 and 0.003.Conclusion:The treatment-related psychological burden of patients with pulmonary tuberculosis in Southern Xinjiang is affected by many factors,such as education level,disease cognition,family function,family support,treatment satisfaction and medication compliance.Family function and family support indirectly affect psychological burden through medication compliance.关键词
结核,肺/心理过程/模型,结构/因素分析,统计学Key words
Tuberculosis,pulmonary/Mental processes/Models,structural/Factor analysis,statistical分类
医药卫生引用本文复制引用
张雅莹,王森路,古丽孜巴·库尔班江,阿卜力克木·艾力,梁辰,袁双龙,李彩虹,曹明芹..新疆维吾尔自治区南疆地区肺结核患者治疗相关心理负担影响因素及其作用路径分析[J].中国防痨杂志,2026,48(6):821-829,9.基金项目
国家自然科学基金项目(82460669) National Natural Science Foundation of China(82460669) （82460669）
