摘要
Abstract
Objective To investigate the correlation between cartilage injury,bone marrow edema and osteoporosis in pa-tients with knee osteoarthritis(KOA)using quantitative computed tomography(QCT).Methods A retrospective analysis was performed on chest CT and clinical data of 86 patients with LOA between January 2020 and December 2022.The patients in-cluded 23 males and 63 females,aged from 42 to 74 years with a mean age of(57.72±7.97)years.Bone mineral density(BMD)of T12 and L1 vertebrae was measured using QCT.According to Outerbridge classification,patients were graded into grade 2,grade 3,and grade 4 cartilage injury.Bone marrow edema was evaluated on knee MRI.The differences in BMD among different grades of cartilage injury were compared,and correlation analysis and partial correlation analysis were performed.The incidence of osteoporosis was compared between groups with and without bone marrow edema,and the correlation between BMD values and bone marrow edema was analyzed.Results There were statistically significant differences in age,T12 and L1 BMD,and the incidence of osteoporosis among different cartilage injury grades(P＜0.001).Statistically significant differences were observed in BMD between grade 2 and grade 3,and between grade 2 and grade 4(P＜0.001),while no significant differ-ence was found between grade 3 and grade 4(P＞0.05).The severity of cartilage injury was inversely correlated with T12,T12＊,L1 BMD,and M-BMD,with r values of-0.377,-0.382,-0.437,and-0.407,respectively(all P＜0.001).After adjusting for con-founding factors including age,BMI,and gender using partial correlation analysis,the severity of cartilage injury still showed a certain inverse correlation with M-BMD(r=-0.210,P=0.033).The incidence of osteoporosis was higher in patients with bone marrow edema than in those without bone marrow edema.Bone marrow edema was inversely correlated with T12,T12＊ BMD,and M-BMD,with r values of-0.242,-0.246,-0.208,and-0.227,respectively(all P＜0.05).Conclusion In patients with KOA,T12 and L1 BMD gradually decreased and the incidence of osteoporosis gradually increased with the worsening of cartilage injury.T12 and L1 BMD were lower in KO A patients with bone marrow edema than in those without bone marrow edema.关键词
膝关节/定量CT/骨密度/软骨损伤/骨髓水肿Key words
Knee joint/Quantitative computed tomography(QCT)/Bone mineral density(BMD)/Cartilage in-jury/Bone marrow edema分类
医药卫生
