中国康复理论与实践2026，Vol.32Issue(5)：577-587,11.DOI:10.3969/j.issn.1006-9771.2026.05.008
小脑间歇性θ脉冲刺激对脑卒中患者姿势控制和跌倒风险的效果
Effect of cerebellar intermittent theta-burst stimulation on postural control and fall risk in patients with stroke
摘要
Abstract
Objective To investigate the effect of cerebellar intermittent theta-burst stimulation(iTBS)on postural control and fall risk in stroke patients. Methods From October,2024 to August,2025,45 stroke patients were recruited from Huadong Hospital Affiliated to Fu-dan University.They were randomly divided into control group(n=15),group A(n=15)and group B(n=15).All the groups received conventional medication and rehabilitation.Group A was additionally administered iTBS over the ipsilesional primary motor cortex(M1),while group B received iTBS over the contralesional cerebel-lum,for three weeks.Before and after intervention,postural stability indexes(eyes open/closed),limits of stabili-ty,directional control score and reaction time were measured using Biodex Balance System,and they were as-sessed with Berg Balance Scale(BBS),Timed Up&Go Test(TUGT)and 10-meter walk test(10MWT). Results After intervention,significant group-time interaction effects were observed for eyes open/closed postural stabili-ty indexes,limits of stability,directional control score,reaction time,BBS score,TUGT and 10MWT(F>23.487,P<0.001).All the groups improved in all the indexes after intervention(P<0.01).The eyes open/closed postural stability indexes,limits of stability,directional control score and reaction time were the best in group B,followed by group A,and the worst in the control group(P<0.05),while BBS,TUGT and 10MWT were better in groups A and B than in the control group(P<0.05). Conclusion Cerebellar iTBS can effectively improve postural control disorders and reduce fall risk in stroke patients,and may be superior to M1 iTBS.关键词
脑卒中/间歇性θ脉冲刺激/小脑/初级运动皮质/平衡/姿势控制/跌倒Key words
stroke/intermittent theta-burst stimulation/cerebellum/primary motor cortex/balance/postural control/fall分类
医药卫生引用本文复制引用
李欣源,郑洁皎,吴雪娇,段林茹,高羽飞..小脑间歇性θ脉冲刺激对脑卒中患者姿势控制和跌倒风险的效果[J].中国康复理论与实践,2026,32(5):577-587,11.基金项目
上海市科委"科技创新行动计划"医学创新研究专项重大疑难疾病诊疗方案(策略)临床研究项目(No.22Y31900200) Supported by Shanghai Science and Technology Commission Science and Technology Innovation Action Plan Clinical Research on Diagnosis and Treatment Plan(Strategy)for Major Difficult Diseases(No.22Y31900200) （策略）
