中国临床药理学杂志2026，Vol.42Issue(6)：759-763,5.DOI:10.13699/j.cnki.1001-6821.2026.06.002
普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响
Efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism and its impact on thyroid function
摘要
Abstract
Objective To explore and analyze the efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism,its impact on thyroid function.Methods Patients with hyperthyroidism were collected and assigned into treatment group and control group.The control group was treated with iodine-131 alone;the treatment group was treated with a combination of propranolol and iodine-131.The efficacy,anxiety(self-rating anxiety scale,SAS)scores and depression(self-rating depression scale,SDS)scores,thyroid hormone levels,cardiac function indicators,and adverse reactions were compared between the two groups.Results A total of 160 patients were enrolled,with 80 cases in each group.There was no significant difference in efficacy between the treatment group and the control group(P＞0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).After treatment,the SAS score,SDS score,free triiodothyronine(FT3)level,free thyroxine(FT4)level,left ventricular ejection fraction(LVEF)level,stroke volume(SV)level,heart rate level in both groups decreased,and the treatment group was lower than the control group(all P＜0.05);the TSH level increased,and the treatment group was higher than the control group(P＜0.05).Conclusion Compared with the use of iodine-131 alone,the combined treatment of propranolol and iodine-131 for hyperthyroidism can effectively improve thyroid function and cardiac function,and reduce anxiety and depression in patients.关键词
普萘洛尔/放射性药物碘-131/甲状腺功能亢进症/甲状腺激素/心功能Key words
propranolol/radiopharmaceutical iodine-131/hyperthyroidism/thyroid hormone/cardiac function分类
医药卫生引用本文复制引用
高秀秀,张星,李娟..普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响[J].中国临床药理学杂志,2026,42(6):759-763,5.基金项目
榆林市科技计划资助项目(20210362) （20210362）
