中国临床药理学杂志2026，Vol.42Issue(6)：770-775,6.DOI:10.13699/j.cnki.1001-6821.2026.06.004
赖脯胰岛素联合平衡盐溶液治疗急诊成人糖尿病酮症酸中毒患者的临床观察
Clinical observation of insulin lispro combined with balanced salt solution in the treatment of adult emergency patients with diabetic ketoacidosis
摘要
Abstract
Objective To explore the clinical effect of insulin lispro combined with balanced salt solution in the treatment of adult emergency patients with diabetic ketoacidosis(DKA).Methods DKA patients were divided into a control group and an experimental group according to the treatment method.Both groups were given intravenous infusion of balanced salt solution for rehydration at the same time.The control group was given insulin aspart,and the experimental group was given insulin lispro.The blood glucose control efficacy,improvement of acidosis,and safety were compared between the two groups.Results There were 44 patients enrolled in the control group and 48 patients in the experimental group.After treatment,the fasting blood glucose(FBG)of the control group was(5.77±1.08)mmol·L-1,the 2-hour postprandial glucose(2 h PG)was(12.11±4.27)mmol·L-1,the mean amplitude of glycemic excursions(MAGE)was(3.48±1.04)mmol·L-1,the 24-hour mean blood glucose(24 h MBG)was(7.84±1.57)mmol·L-1,the beta-hydroxybutyrate(β-HB)was(0.35±0.11)mmol·L-1,the carbon dioxide combining power(CO2 CP)was(20.06±6.43)mmol·L-1,and the potential of hydrogen(pH)value was 7.58±1.13.For the experimental group,the FBG was(5.36±1.26)mmol·L-1,the 2 h PG was(10.22±2.52)mmol·L-1,the MAGE was(3.32±0.92)mmol·L-1,the 24 h MBG was(7.60±1.44)mmol·L-1,the β-HB was(0.30±0.14)mmol·L-1,the CO2CP was(21.34±6.54)mmol·L-1,and the pH was 7.55±1.07.The experimental group had significantly lower levels of FBG,2 h PG,MAGE,and 24 h MBG compared to the control group(all P＜0.05).There was no significant difference in β-HB,CO2CP,and pH value between the two groups(all P＞0.05).There was 1 case of hypoglycemia in the control group and 3 cases of hypoglycemia in the experimental group.There were no gastrointestinal adverse reactions such as abdominal distension in both groups,and there was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Insulin lispro combined with balanced salt solution can effectively control blood glucose,improve acidosis and electrolyte levels,exert no significant adverse effects on renal function,and has good safety in the treatment of adult emergency DKA patients.关键词
赖脯胰岛素/平衡盐溶液/糖尿病酮症酸中毒/酸中毒/急诊/血糖控制Key words
insulin lispro/balanced salt solution/diabetic ketoacidosis/acidosis/emergency treatment/glycemic control分类
医药卫生引用本文复制引用
程超,郁慧杰..赖脯胰岛素联合平衡盐溶液治疗急诊成人糖尿病酮症酸中毒患者的临床观察[J].中国临床药理学杂志,2026,42(6):770-775,6.基金项目
嘉兴市急诊医学重点支撑学科建设项目(2023-ZC-004) （2023-ZC-004）
