中国临床药理学杂志2026，Vol.42Issue(7)：1002-1004,3.DOI:10.13699/j.cnki.1001-6821.2026.07.016
成功救治复杂性腹腔感染致碳青霉烯耐药大肠埃希菌脓毒症1例
A successfully treated case of carbapenem resistant Escherichia coli sepsis caused by complex intra-abdominal infection
崔洪 1李俊 1姜良坤 2马嘉蹊 2汪波2
作者信息
- 1. 北京大学第一医院,感染疾病科,北京 100034
- 2. 北京大学第一医院,急诊科,北京 100034
- 折叠
摘要
Abstract
Objective To explore the efficacy of eravacycline combined with colistimethate sodium in treating sepsis caused by carbapenem-resistant Escherichia coli producing New Delhi metallo-β-lactamase(NDM)secondary to complex intra-abdominal infection.Methods The anti-infection regimen was dynamically adjusted according to abdominal-pelvic enhanced MRI,laboratory tests,changes in main inflammatory indicators(peripheral blood white blood cell count and procalcitonin),and drug sensitivity test results.Results After 13 days of treatment with eravacycline(50 mg,q12h)and colistimethate sodium(150 mg,q12h),the patient's condition and inflammatory indicators improved significantly,with no drug-related adverse reactions during hospitalization.Conclusion The combination is safe and effective for the above-mentioned sepsis,providing crucial technical support for clinical treatment of NDM-producing carbapenem-resistant Escherichia coli infections.关键词
依拉环素/多黏菌素E甲磺酸钠/碳青霉烯耐药大肠埃希菌/脓毒症Key words
eravacycline hydrochloride for injection/colistimethate sodium for injection/carbapenem resistant Escherichia coli/sepsis分类
医药卫生引用本文复制引用
崔洪,李俊,姜良坤,马嘉蹊,汪波..成功救治复杂性腹腔感染致碳青霉烯耐药大肠埃希菌脓毒症1例[J].中国临床药理学杂志,2026,42(7):1002-1004,3.
