中国临床药理学杂志2026，Vol.42Issue(7)：1005-1010,6.DOI:10.13699/j.cnki.1001-6821.2026.07.017
基于肠-关节轴探讨中药干预强直性脊柱炎的研究现状
A review of the current state of research on traditional chinese medicine interventions for ankylosing spondylitis based on the gut-joint axis
摘要
Abstract
Ankylosing spondylitis(AS)is an inflammatory autoimmune disease characterised primarily by chronic lower back pain.Its aetiology is complex,with a tendency to run in families,and is associated with factors such as genetics,the immune system and microbial infections.As a vital digestive and immune organ,the gut harbours a diverse microbial community;an imbalance in this microbiota may contribute to the development of AS via the"gut-joint axis".Consequently,this paper elucidates the fundamental principles of the"gut-joint axis"and its relationship with the onset and progression of AS.It summarises the latest research findings on the use of traditional chinese medicine to treat AS by regulating the gut microbiome,optimising microbial metabolism,improving intestinal permeability,and activating the intestinal mucosal immune system.The aim is to provide a reference for further research into the treatment of AS using traditional chinese medicine via the"gut-joint axis".关键词
中药/强直性脊柱炎/肠-关节轴/肠道菌群Key words
Chinese medicine/ankylosing spondylitis/gut-joint axis/gut microbiota分类
医药卫生引用本文复制引用
宋静静,杨娟娟,李浩林,芦栋生,苏瑾,李永红,金芳梅,陈平,王海东..基于肠-关节轴探讨中药干预强直性脊柱炎的研究现状[J].中国临床药理学杂志,2026,42(7):1005-1010,6.基金项目
甘肃省科技计划基金资助项目(23JRRA1535) （23JRRA1535）
