中国免疫学杂志2026，Vol.42Issue(5)：1025-1031,7.DOI:10.3969/j.issn.1000-484X.2026.05.001
浆细胞样树突状细胞的免疫调控机制与靶向治疗研究进展
Advances in immunoregulatory mechanisms and targeted therapy of plasmacytoid dendritic cells
摘要
Abstract
Under physiological conditions,plasmacytoid dendritic cells(pDCs)exhibit high functional plasticity,enabling a dynamic transition between type Ⅰ interferon secretion and antigen presentation in response to microenvironmental signals.These distinct functional states support early antiviral innate immunity and initiation of adaptive immune responses,respectively.However,dysregulation of this plasticity is closely associated with disease pathogenesis.In autoimmune conditions such as systemic lupus erythe-matosus,pDCs adopt an abnormally activated phenotype characterized by sustained type Ⅰ interferon overproduction,which drives chronic inflammation and autoimmune pathology.Conversely,within tumor microenvironment,antigen-presenting function of pDCs is suppressed,leading to local immune tolerance and promoting tumor immune evasion.This review focuses on physiological basis and pathological disruption of pDCs plasticity,systematically elaborating its regulatory mechanisms,disease relevance,and emerging ther-apeutic strategies.关键词
浆细胞样树突状细胞/功能可塑性/异常活化/免疫耐受/靶向治疗Key words
Plasmacytoid dendritic cells/Functional plasticity/Aberrant activation/Immune tolerance/Targeted therapy分类
医药卫生引用本文复制引用
吴江雅婷,刘若虚,张纪岩,袁增强..浆细胞样树突状细胞的免疫调控机制与靶向治疗研究进展[J].中国免疫学杂志,2026,42(5):1025-1031,7.基金项目
国家自然科学基金(82530063). （82530063）
