中国奶牛Issue(4)：14-19,6.DOI:10.19305/j.cnki.11-3009/s.2026.04.004
家牛MYLK4基因生物信息学分析
Bioinformatics Analysis of MYLK4 Gene in Bos taurus
摘要
Abstract
As an important regulator of muscle growth and development,MYLK4 gene plays an important role in muscle contraction,cell proliferation and differentiation,and is closely related to the growth and development of animals.In order to further explore the functional structure and characteristics of MYLK4 gene in Bos taurus,bioinformatics databases and related software were used to predict and analyze the gene and its coding products.The results showed that the coding region of Bos taurus MYLK4 gene was 1170 bp,encoding 389 amino acids,the molecular formula was C1947H3085N533O595S20,and the molecular weight was 44121.33 Da.The theoretical isoelectric point was 5.31,the half-life was 30 h,and the instability index was 45.77.The protein lacks transmembrane domains and is an unstable hydrophilic protein localized primarily to the nucleus and cytoplasm.Secondary and tertiary structure predictions indicated dominance of random coils and α-helices.There is 1 potential glycosylation site,26 phosphorylation sites and 10 interacting proteins.In addition,phylogenetic tree analysis showed that Bos taurus were most closely related to Bos mutus,and most distantly related to Mus musculus.This result can provide a theoretical reference for further exploring the improvement of growth traits and optimal breeding of MYLK4 gene in Bos taurus.关键词
牛/MYLK4基因/生物信息学Key words
Bos taurus/MYLK4 gene/Bioinformatics analysis分类
农业科技引用本文复制引用
姜世光,麻俊渊,才增拉毛,李平,木尼尔丁·依拉丁,王宏,何文..家牛MYLK4基因生物信息学分析[J].中国奶牛,2026,(4):14-19,6.基金项目
东西部科技协作专项(25CXNP004) （25CXNP004）
甘南州重点研发计划(2024ZY1NC001). （2024ZY1NC001）
