中国普通外科杂志2026，Vol.35Issue(3)：488-499,12.DOI:10.7659/j.issn.1005-6947.250646
外周血白细胞计数与胰腺癌风险因果关联的孟德尔随机化研究
Peripheral white blood cell counts and pancreatic cancer risk:a Mendelian randomization study
孙晶 1刘雍容 2张欣 3常婧妤 1周女樱2
作者信息
- 1. 中南大学湘雅三医院 儿科,湖南 长沙 410013||中南大学湘雅三医院 护理部,湖南 长沙 410013
- 2. 中南大学湘雅三医院 护理部,湖南 长沙 410013
- 3. 湖南省湘潭市第二人民医院 消化内科,湖南 湘潭 411100
- 折叠
摘要
Abstract
Background and Aims:Pancreatic cancer has an extremely poor prognosis,and effective screening strategies for the general population are lacking.Circulating white blood cells are accessible immunoinflammatory markers,but their causal relationship with pancreatic cancer risk remains unclear.This study aimed to systematically evaluate the potential causal associations between peripheral white blood cell counts and pancreatic cancer risk using Mendelian randomization(MR).
Methods:A two-sample MR design was applied.GWAS summary statistics for total white blood cell count and five major subtypes were obtained from the Blood Cell Consortium.Pancreatic cancer outcome data were derived from FinnGen release 12(European population),with additional validation using East Asian GWAS datasets.The inverse-variance weighted(IVW)method was used as the primary analysis,complemented by multivariable MR,reverse MR,and multiple sensitivity analyses.
Results:Univariable MR analysis showed that genetically predicted higher eosinophil count was associated with a lower risk of pancreatic cancer(IVW:OR=0.886,95%CI=0.793-0.990,P=0.033),with consistent direction across methods.Multivariable MR confirmed that this protective association persisted after adjusting for other leukocyte subtypes(OR=0.848,95%CI=0.723-0.995,P=0.043).Reverse MR provided no evidence for a causal effect of pancreatic cancer on white blood cell traits.The East Asian validation analysis showed a consistent direction of effect.No robust associations were observed for other leukocyte traits.
Conclusion:Genetically predicted higher eosinophil levels may be associated with a reduced risk of pancreatic cancer.These findings provide supportive evidence for the immunoetiology of pancreatic cancer,but are not yet sufficient for direct clinical application.关键词
胰腺肿瘤/白细胞/嗜酸细胞/孟德尔随机化分析Key words
Pancreatic Neoplasms/Leukocytes/Eosinophils/Mendelian Randomization Analysis分类
医药卫生引用本文复制引用
孙晶,刘雍容,张欣,常婧妤,周女樱..外周血白细胞计数与胰腺癌风险因果关联的孟德尔随机化研究[J].中国普通外科杂志,2026,35(3):488-499,12.
