中国水产科学2026，Vol.33Issue(4)：76-87,12.DOI:10.12264/JFSC2025-0238
总溶解气体过饱和对似鲇高原鳅生理功能的影响
Effects of total dissolved gas supersaturation on the physiological functions of Triplophysa siluroides
摘要
Abstract
During flood discharge,total dissolved gas(TDG)supersaturation downstream of dams can cause gas-bubble disease in fish and has become a globally ecological concern.However,the impact of this condition on fish physiology remains unclear.In this study,we systematically examined the histopathology,serum biochemistry,transcriptomes and metabolites of Triplophysa siluroides exposed to 116%TDG.T.siluroides exhibited severe gill pathology,elevated catalase(CAT)and aspartate aminotransferase(AST)activities,up-regulation of cytochrome,immune(cd48 and cd151)and glycolytic(phosphoglycerate mutase2)genes,and global depletion of glycerophospholipids.Integrated transcriptomic and metabolomic analyses revealed that differentially expressed genes and metabolites were co-enriched in three biological pathways:pyrimidine metabolism,amino acid biosynthesis,and steroid hormone biosynthesis.The results of this study demonstrate that TDG supersaturation induces physiological damage in T.siluroides,triggers an oxidative stress response,and alters the expression of downstream regulatory genes.These findings contribute to a deeper understanding of the molecular mechanisms underlying fish responses to TDG supersaturation stress and provide essential data for developing effective fish conservation strategies and ecological flow management practices.关键词
总溶解气体过饱和/氧化应激/似鲇高原鳅/组织病理学/基因表达/代谢物谱Key words
total dissolved gas supersaturation/oxidative stress/Triplophysa siluroides/histopathology/gene expression/metabolite profile分类
农业科技引用本文复制引用
陈叶雨,罗晓含,刘晓庆,吴晓雲,赖见生..总溶解气体过饱和对似鲇高原鳅生理功能的影响[J].中国水产科学,2026,33(4):76-87,12.基金项目
四川省自然科学基金项目(2025ZNSFSC0276) （2025ZNSFSC0276）
农业农村部财政专项"黄河渔业资源与环境调查"项目 （）
国家大宗淡水鱼产业技术体系项目(CARS-45-51) （CARS-45-51）
四川省科技计划项目(2021YFYZ0015). （2021YFYZ0015）
