中国实验方剂学杂志2026，Vol.32Issue(11)：77-86,10.DOI:10.13422/j.cnki.syfjx.20260921
黄连解毒汤抗急性缺血性中风研究进展
Huanglian Jiedutang Against Acute Ischemic Stroke:A Review
摘要
Abstract
Huanglian Jiedutang(HLJDT),as a classical formula for clearing heat and removing toxins,has been widely applied in the treatment of various clinical diseases in recent years,particularly during the fire-heat stage of stroke,where it has attracted considerable attention.Based on previous studies,this paper systematically elaborates on the research progress on the active components of HLJDT,its clinical application in ischemic stroke,and advances in studies on its mechanisms of action.Modern pharmacological studies have demonstrated that HLJDT contains multiple active components,including baicalin,geniposide,and berberine.In the treatment of ischemic stroke,these components exert therapeutic effects through multi-target,multi-pathway,and multi-level mechanisms.Clinical studies have shown that HLJDT can increase cerebral blood flow,reduce cerebral infarct volume,and improve post-stroke physical dysfunction in patients with ischemic stroke.Experimental studies have indicated that HLJDT can improve neurological function scores and increase cerebral perfusion in experimental stroke models.In addition,the mechanisms underlying the anti-ischemic stroke effects of HLJDT may be related to anti-inflammatory and antioxidant activities,promotion of angiogenesis,and regulation of amino acid and energy metabolism.Although existing studies have confirmed that HLJDT exhibits multi-target and multi-pathway synergistic therapeutic characteristics,further large-sample randomized controlled trials are still needed to verify its long-term efficacy and to further elucidate the dynamic interaction network among components,targets,and pathways.Combined with network pharmacology and molecular docking analyses,this study further clarifies the synergistic targets of the core components(berberine,baicalin,and geniposide),providing a theoretical basis for in-depth research and clinical translation of HLJDT in the treatment of ischemic stroke.关键词
黄连解毒汤/缺血性中风/活性成分/临床应用/实验研究/多靶点调控Key words
Huanglian Jiedutang/ischemic stroke/active ingredient/clinical application/experimental research/multi-target regulation分类
医药卫生引用本文复制引用
董利洋,程发峰,王庆国,张钦渊,武怡平,何颖萍,邵威,张浩嘉,王雪茜,李长香,崔友祥..黄连解毒汤抗急性缺血性中风研究进展[J].中国实验方剂学杂志,2026,32(11):77-86,10.基金项目
国家自然科学基金区域联合重点支持项目(U21A20400) （U21A20400）
河北省自然科学基金项目(H2024110042) （H2024110042）
河北省中西医结合神经康复重点实验室项目(SZX201318) （SZX201318）
