中国听力语言康复科学杂志2026，Vol.24Issue(3)：267-271,5.DOI:10.3969/j.issn.1672-4933.2026.03.010
肥胖与良性阵发性位置性眩晕的关联机制综述
Mechanistic Links Between Obesity and Benign Paroxysmal Positional Vertigo:A Review
摘要
Abstract
Benign paroxysmal positional vertigo(BPPV)is the most common peripheral vestibular disorder in clinical practice,with an estimated lifetime prevalence of approximately 2.4%.Although otoconial dislodgement is the fundamental pathological basis,increasing attention has been paid to the contribution of systemic factors-particularly metabolic and nutritional status-to disease onset,recurrence,and clinical outcomes.Against the backdrop of the global obesity epidemic,the association between obesity and BPPV has become a focus of investigation;however,current evidence does not support a consistent direct causal relationship.By synthesizing available epidemiological,pathophysiological,and clinical data,this review shows that most cross-sectional studies report an association between overweight/obesity and BPPV prevalence,yet the association often attenuates or disappears after multivariable adjustment,and Mendelian randomization analyses have not identified obesity as an independent risk factor.Mechanistically,obesity is more likely to influence BPPV through indirect pathways,including metabolic syndrome-related microvascular dysfunction,chronic low-grade inflammation and oxidative stress,disrupted vitamin D/calcium homeostasis,and sarcopenia,thereby destabilizing the inner-ear microenvironment and otoconia and ultimately increasing susceptibility to onset and recurrence while reducing therapeutic benefit.Clinically,in addition to standardized canalith repositioning procedures,a comprehensive strategy integrating"metabolic intervention plus vestibular protection"is warranted.This includes screening and control of metabolic comorbidities,optimized vitamin D/calcium supplementation,resistance training with preservation of muscle function,and long-term follow-up within a multidisciplinary care model.Future work should prioritize large prospective cohorts,refined body-composition phenotyping,and targeted interventional trials to clarify key links and optimize individualized management.关键词
肥胖/良性阵发性位置性眩晕/代谢综合征/肌肉减少症/维生素D/病理生理机制/临床管理Key words
Obesity/Benign paroxysmal positional vertigo/Metabolic syndrome/Sarcopenia/Vitamin D/Pathophysiology/Clinical management分类
医药卫生引用本文复制引用
刘兴健,李娟娟,杜一,任丽丽,吴子明..肥胖与良性阵发性位置性眩晕的关联机制综述[J].中国听力语言康复科学杂志,2026,24(3):267-271,5.基金项目
2025年深圳市基础研究专项自然科学基金计划项目"Ⅰ型胶原通过整合素增强外泌体摄取促进耳蜗毛细胞再生治疗突发性耳聋的分子机制"(JCYJ20250604123259001) （JCYJ20250604123259001）
