中国现代医学杂志2026，Vol.36Issue(9)：65-71,7.DOI:10.3969/j.issn.1005-8982.2026.09.010
脱碘酶在代谢功能障碍相关脂肪性肝病中的时空表达与作用机制研究进展
The spatiotemporal expression and mechanistic roles of deiodinases in metabolic dysfunction-associated steatotic liver disease
摘要
Abstract
Deiodinases(DIOs)are a class of selenocysteine-containing enzymes that play a crucial role in regulating intracellular thyroid hormone activity and maintaining systemic metabolic homeostasis.Metabolic dysfunction-associated steatotic liver disease(MASLD)is a form of liver injury characterized by metabolic dysregulation and lipid accumulation,which subsequently leads to lipotoxicity and immune-mediated inflammatory damage.In recent years,growing research has focused on the role of thyroid hormones in MASLD,while the understanding of DIOs remains to be further elucidated.This review summarizes recent advances in the study of how DIOs influence hepatic metabolic status,explores the mechanisms through which DIOs contribute to the pathogenesis of MASLD,and suggests potential therapeutic targeting of DIOs for this condition.关键词
脱碘酶/代谢功能障碍相关脂肪性肝病/甲状腺激素/时空特异性/发病机制Key words
deiodinases/metabolic dysfunction-associated steatotic liver disease/thyroid hormones/spatiotemporal specificity/pathogenesis分类
医药卫生引用本文复制引用
牛佳乐,牛剑祥..脱碘酶在代谢功能障碍相关脂肪性肝病中的时空表达与作用机制研究进展[J].中国现代医学杂志,2026,36(9):65-71,7.基金项目
国家自然科学基金(82473613) （82473613）
内蒙古医科大学联合项目(YKD2023LH046) （YKD2023LH046）
内蒙古医学科学院公立医院科研联合基金科技项目(2025GLLH0201) （2025GLLH0201）
