中国心理卫生杂志2026，Vol.40Issue(6)：461-467,7.DOI:10.3969/j.issn.1000-6729.2026.06.01
抑郁症脑前额叶与颞叶激活特征及其与临床症状和认知功能的关系
Prefrontal and temporal hemodynamic characteristics of patients with major depressive disorder and their associations with clinical symptoms and cognitive function
摘要
Abstract
Objective:To investigate cognitive function of patients with major depressive disorder(MDD),ex-amine frontotemporal lobe hemodynamic responses during the verbal fluency text(VFT)task in patients with MDD,and explore their correlation with depressive symptoms,anxiety symptoms,and severity of cognitive dysfunc-tion.Methods:Forty MDD patients and 40 normal controls matched by age,gender and years of education were en-rolled.The Hamilton Depression Scale(HAMD),Beck Depression Inventory(BDI),Hamilton Anxiety Scale(HA-MA)and Beck Anxiety Inventory(BAI)were used to evaluate the severity of clinical symptoms.The cognitive function of all subjects was evaluated by Digit Symbol Substitution Test(DSST),Digita Span Test(DST),Seman-tic Verbal Fluency task(SVF)and Phonological Verbal Fluency task(PVF).Subjects were monitored for prefrontal and bilateral temporal lobe hemodynamic characteristics during the VFT using functional near-infrared spectroscopy.Results:Compared with controls,the DSST scores(P＜0.001),PVF total scores(P＜0.001),and prefrontal lobe integral values(P＜0.05)were lower in the MDD group than in the normal control group.The pre-frontal center of gravity values in the MDD group were positively correlated with the HAMD retardation factor scores(r=0.33,P＜0.05),while the bilateral temporal lobe integral values were negatively correlated with the HAMD hopelessness factor scores(r=-0.35,P＜0.05).Conclusion:Patients with MDD exhibit notable cogni-tive impairment,and the hemodynamic characteristics of their frontal and temporal lobes are correlated with the se-verity of their clinical symptoms.关键词
抑郁症/功能性近红外光谱成像/认知功能/临床症状/焦虑Key words
functional near-infrared spectroscopy/cognitive function/clinical symptom/anxiety/major de-pressive disorder分类
医药卫生引用本文复制引用
张怡璇,刘聪,顾乔乔,全柯铭,潘斌,王禹霏,雷沁霖,王慧颖,王长虹..抑郁症脑前额叶与颞叶激活特征及其与临床症状和认知功能的关系[J].中国心理卫生杂志,2026,40(6):461-467,7.基金项目
河南省重点研发专项(221111311000),新乡市重大科技专项(ZD2020011),精神心理疾病防治河南省协同创新中心项目基金(XTgh03),中原英才计划(育才系列) （221111311000）
