中国药物评价2026，Vol.43Issue(2)：128-132,5.
清金化痰汤对慢性阻塞性肺疾病症状恢复及Nrf2/HO-1信号通路的影响
Effect of Qingjin Huatan Decoction on the Nrf2/HO-1 Signaling Pathway and Symptom Recovery in Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective:To observe of the effect of Qingjin huatan decoction on Nrf2/HO-1 and symptom recovery in patients with chron-ic obstructive pulmonary disease(COPD).Methods:A prospective study was conducted on 118 COPD patients who visited our hospital from September 2023 to May 2025,and a parallel controlled trial was designed.They were divided into a control group and an experimental group using a simplified random number table method,with 59 cases in each group.The control group received conventional Western medicine treatment,while the experimental group received Qingjin Huatan decoction combined with conventional Western medi-cine.The syndrome scores,Nrf2/HO-1 signaling pathway proteins,oxidative stress,inflammatory indicators and rehabilitation process of the two groups of patients were compared.Analyze the correlation between Nrf2/HO-1 signaling pathway proteins and clinical indicators.Results:After treatment,the scores of symptoms such as cough with yellow phlegm,chest stuffiness and asthma,fever and thirst and restlessness in the experimental group were lower than those in the control group(P＜0.05).The relative expression levels of serum Nrf2 and HO-1 in the experimental group were higher than those in the control group(P＜0.05).The level of SOD in the experimental group was higher than that in the control group,while the MDA,WBC and Neu were lower than those in the control group(P＜0.05).The relief time of dyspnea,cough,sputum and activity tolerance in the experimental group were lower than those in the control group(P＜0.05).Nrf2 and HO-1 are positively correlated with SOD and negatively correlated with MDA,WBC and Neu(r=0.745,-0.802,-0.739,-0.779,0.795,-0.773,-0.725,-0.719;P＜0.05).Conclusion:Qingjin huatan decoction can alleviate the clinical symptoms of COPD patients,and has a positive effect on reducing oxidative stress,inflammatory response and accelerating the recovery process of patients.Its mechanism of action may be related to the activation of the Nrf2/HO-1 pathway.关键词
慢性阻塞性肺疾病/清金化痰汤/核因子E2相关因子2/血红素加氧酶-1/证候积分/康复进程Key words
Chronic obstructive pulmonary disease/Qingjin huatan decoction/Nuclear factor E2 related factor 2/heme oxygenase 1/Syndrome score/Rehabilitation process分类
医药卫生引用本文复制引用
张彬,高会军..清金化痰汤对慢性阻塞性肺疾病症状恢复及Nrf2/HO-1信号通路的影响[J].中国药物评价,2026,43(2):128-132,5.基金项目
河南省医学科技攻关项目(LHGJ2024102010) （LHGJ2024102010）
