中国医学创新2026，Vol.23Issue(11)：14-18,5.DOI:10.3969/j.issn.1674-4985.2026.11.004
左卡尼汀联合连续性肾脏替代疗法治疗慢性肾衰竭的效果
Effects of Levocarnitine Combined with Continuous Renal Replacement Therapy in the Treatment of Chronic Renal Failure
王金龙 1聂翠芝 2龚梦迪2
作者信息
- 1. 徐州市中医院肾内科 江苏 徐州 221000
- 2. 徐州市中医院血液透析中心 江苏 徐州 221000
- 折叠
摘要
Abstract
Objective:To explore the clinical effect of Levocarnitine combined with continuous renal replacement therapy(CRRT)in patients with chronic renal failure(CRF).Method:A total of 102 patients with CRF admitted to Xuzhou Traditional Chinese Medicine Hospital from June 2021 to June 2024 were selected for a double-blind controlled analysis trial.The patients were divided into the experimental group(n=51)and the control group(n=51)by the random number table method.The treatment plan for the control group was CRRT,and that for the experimental group was Levocarnitine combined with CRRT.The total effective rate of treatment,renal function indicators,nutritional indicators,inflammatory factor indicators and oxidative stress indicators were compared between the two groups.Result:After 3 months of treatment,the experimental group had higher total effective rate of treatment than control group(P<0.05).After 3 months of treatment,the experimental group had lower Scr,BUN and 24-hour urine protein quantification than control group(P<0.05).After 3 months of treatment,the experimental group had higher Hb and albumin(ALB)than control group(P<0.05).After 3 months of treatment,the experimental group had lower IL-6,TNF-α and CRP than control group(P<0.05).After 3 months of treatment the experimental group had lower malondialdehyde(MDA)and superoxide dismutase(SOD)than control group,and higher glutathione peroxidase(GSH-Px)than control group(P<0.05).Conclusion:The treatment of CRF patients with Levocarnitine combined with CRRT has a significant effect,which can improve renal function and nutritional status,and alleviate inflammatory and oxidative stress responses.关键词
左卡尼汀/连续性肾脏替代疗法/慢性肾衰竭Key words
Levocarnitine/Continuous renal replacement therapy/Chronic renal failure引用本文复制引用
王金龙,聂翠芝,龚梦迪..左卡尼汀联合连续性肾脏替代疗法治疗慢性肾衰竭的效果[J].中国医学创新,2026,23(11):14-18,5.
