中国医学创新2026，Vol.23Issue(11)：40-44,5.DOI:10.3969/j.issn.1674-4985.2026.11.010
替罗非班联合西洛他唑治疗早期神经功能恶化穿支动脉粥样硬化型脑梗死的有效性
Efficacy of Tirofiban Combined with Cilostazol in the Treatment of Perforator Artery Atherosclerosis Cerebral Infarction with Early Neurological Deterioration
摘要
Abstract
Objective:To explore the efficacy and safety of Tirofiban combined with Cilostazol in the treatment of perforator artery atherosclerosis cerebral infarction with early neurological deterioration.Method:Seventy patients with perforator artery atherosclerosis cerebral infarction who experienced early neurological deterioration during hospitalization at the Department of Neurology,Wuxi Xinwu District Xinrui Hospital from January 2024 to September 2025 were retrospectively collected as the study subjects and divided into two groups according to different treatment plans,with 35 cases in each group.The control group received Tirofiban combined with Clopidogrel and Aspirin,the observation group received Tirofiban combined with Cilostazol and Aspirin.The neurological deficits,daily living abilities,therapeutic effects and the occurrence of adverse reactions were compared between the two groups.Result:The NIHSS scores after 14 and 30 days of treatment and the modified Rankin scale(mRS)score after 30 days of treatment of the observation group were lower than those of the control group(P<0.05).After 30 days of treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For perforator artery atherosclerosis cerebral infarction with early neurological deterioration,the treatment with Tirofiban combined with Cilostazol has significant advantages,it can improve the clinical prognosis of such patients and is also safe.关键词
替罗非班/西洛他唑/早期神经功能恶化/穿支动脉粥样硬化型脑梗死Key words
Tirofiban/Cilostazol/Early neurological deterioration/Perforator artery atherosclerosis cerebral infarction引用本文复制引用
张炜炜,高晴,贾续东,程婧,罗志威,梁华峰..替罗非班联合西洛他唑治疗早期神经功能恶化穿支动脉粥样硬化型脑梗死的有效性[J].中国医学创新,2026,23(11):40-44,5.基金项目
无锡市"太湖人才计划"高端医学专家团队项目(WXTHRC2024) （WXTHRC2024）
上海交通大学医学院附属瑞金医院无锡分院院级课题(2025YJYB002) （2025YJYB002）
