中国医学创新2026，Vol.23Issue(12)：23-27,5.DOI:10.3969/j.issn.1674-4985.2026.12.006
深部热疗联合125I粒子植入治疗肝脏恶性肿瘤的近期效果与安全性
Short-term Efficacy and Safety of Deep Hyperthermia Combined with 125I Particle Implantation in the Treatment of Malignant Hepatic Tumor
摘要
Abstract
Objective:To investigate the short-term efficacy and safety of deep hyperthermia combined with 125I particle implantation in the treatment of malignant hepatic tumor.Method:A total of 68 patients with malignant hepatic tumor admitted to Huadong Hospital Affiliated to Fudan University from November 2023 to June 2025 were selected.They were divided into a treatment group and a control group using a random number table method,with 34 cases in each group.The treatment group was treated with 125I particle implantation combined with deep hyperthermia,and the control group was treated with 125I particle implantation alone.The short-term efficacy,pain degree,quality of life,and the incidence of adverse reactions were compared between the two groups.Result:Three months after particle implantation,the objective response rate(ORR)in the treatment group was 85.3%(29/34),and the disease control rate(DCR)was 100%(34/34),which were significantly higher than 61.8%(21/34)and 82.4%(28/34)of the control group(P<0.05).Before particle implantation,there was no statistically significant difference in the numerical rating scale(NRS)scores between the two groups(P>0.05).At 0.5,1,1.5,2,2.5,and 3 months after particle implantation,the NRS scores of the treatment group were lower than those of the control group(P<0.05).Before particle implantation,there was no statistically significant difference in the Karnofsky performance status(KPS)scores between the two groups(P>0.05).Three months after particle implantation,the KPS scores of both groups were higher than those before implantation,and that in the treatment group was higher than the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The short-term effect of deep hyperthermia combined with 125I particle implantation in the treatment of malignant hepatic tumor is significantly better than that of 125I particle implantation alone.It can more effectively relieve patients'pain,improve their quality of life,and has comparable safety.关键词
深部热疗/125I粒子植入/肝脏恶性肿瘤/原发性肝癌/转移性肝癌/近期疗效Key words
Deep hyperthermia/125I particle implantation/Malignant hepatic tumor/Primary hepatic carcinoma/Metastatic hepatic carcinoma/Short-term efficacy引用本文复制引用
吉永烁,刘玉美,赵洪,朱君秋..深部热疗联合125I粒子植入治疗肝脏恶性肿瘤的近期效果与安全性[J].中国医学创新,2026,23(12):23-27,5.基金项目
中国健康促进基金会-星火计划-肿瘤治疗临床科研创新与发展项目基金(XH-B013) （XH-B013）
