中国医学创新2026，Vol.23Issue(12)：175-182,8.DOI:10.3969/j.issn.1674-4985.2026.12.039
特应性皮炎中皮肤屏障功能障碍与微生物群落失调的研究进展
Research Progress on Skin Barrier Dysfunction and Microbial Community Imbalance in Atopic Dermatitis
摘要
Abstract
Atopic dermatitis(AD)is a chronic inflammatory skin disease characterized primarily by dry skin and recurrent flares.Epidemiological studies have shown that AD is more likely to occur in children,and its prevalence rate is significantly higher than that in the adult population.AD usually begins in early childhood,and some children persisting into adulthood.The pathogenesis of AD is complex,involving many factors such as heredity,immunity and environment.Among them,skin barrier dysfunction and microbial community imbalance are important factors in the onset of AD.The interaction between these two factors forms a vicious cycle of"skin barrier disruption-microbial community imbalance-immune inflammation",jointly participating in the occurrence and development of the disease.This review summarizes the research progress on skin barrier dysfunction and microbial community imbalance in AD,and outlines the treatment strategies for AD based on skin barrier repair,microecological regulation,and immune regulation.It provides theoretical references for the basic research and clinical diagnosis and treatment of AD.关键词
特应性皮炎/皮肤屏障功能/微生物群落/免疫功能失调Key words
Atopic dermatitis/Skin barrier function/Microbial community/Immune dysfunction引用本文复制引用
罗绪梅,黄丰,罗湘淇,孙赟..特应性皮炎中皮肤屏障功能障碍与微生物群落失调的研究进展[J].中国医学创新,2026,23(12):175-182,8.基金项目
云南省青年学术和技术带头人项目(20240AC350042) （20240AC350042）
云南省匡海学专家工作站(202305AF150029) （202305AF150029）
