中国医学科学院学报2026，Vol.48Issue(2)：244-248,5.DOI:10.3881/j.issn.1000-503X.16622
MRI动态对比增强定量参数对鉴别头颈部良恶性病变的临床价值
Clinical Value of Quantitative Parameters of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Distinguishing Between Benign and Malignant Lesions of the Head and Neck
摘要
Abstract
Objective To investigate the clinical value of quantitative parameters derived from dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in distinguishing between benign and malignant le-sions of the head and neck.Methods A retrospective cohort study was conducted.A total of 79 patients with pathologically confirmed space-occupying lesions of the head and neck were enrolled and were assigned into a be-nign group(n=37,including mucosal polyps and inverted papillomas)and a malignant group(n=42,all be-ing squamous cell carcinomas).All the patients underwent preoperative 3.0T MRI conventional sequences and DCE-MRI scans.The Extended Tofts model was adopted to obtain quantitative parameters:volume transfer con-stant(Ktrans),rate constant,and extravascular extracellular space volume fraction(Ve).The Mann-Whitney U test was performed to compare intergroup differences,and receiver operating characteristic curves were generated to evaluate the diagnostic performance of each parameter.Results The malignant group exhibited higher Ktrans[0.250(0.217,0.345)/min vs.0.153(0.132,0.167)/min]and Ve[0.644(0.402,0.880)vs.0.294(0.211,0.437)]than the benign group(both P<0.001).Receiver operating characteristic curves analysis demonstrated that Ktrans had the optimal diagnostic performance(area under the curve=0.923,95%CI=0.167-0.225),with the sensitivity of 88.1%and the specificity of 89.2%at a cut-off value of 0.187/min.Ve showed moderate performance(area under the curve=0.796,95%CI=0.354-0.560),achieving the sensitivity of 85.7%and the specificity of 69.4%at a cut-off value of 0.355.Conclusion Among the quantitative parameters of DCE-MRI,Ktrans demonstrates excellent value for differentiating between benign and malignant lesions of the head and neck,serving as a reliable independent predictor and providing critical imaging evidence for preoperative noninvasive evaluation.关键词
动态对比增强MRI成像/容量转移常数/速率常数/血管外细胞外间隙容积比Key words
dynamic contrast-enhanced magnetic resonance imaging/volume transfer constant/rate con-stant/extravascular extracellular space volume fraction分类
医药卫生引用本文复制引用
鲍林,田亚忠,刘澍,刘梦琦,陈志晔..MRI动态对比增强定量参数对鉴别头颈部良恶性病变的临床价值[J].中国医学科学院学报,2026,48(2):244-248,5.基金项目
国家重点研发计划(2023YFF1203501) （2023YFF1203501）
