中国医学前沿杂志（电子版）2026，Vol.18Issue(3)：18-24,7.DOI:10.12037/YXQY.2026.03-03
岩藻糖基化修饰在抗肿瘤和感染免疫中的研究进展
Progress of fucosylation modification in anti-tumor and infection Immunity
摘要
Abstract
Fucosylation is one of the common types of glycosylation modifications,and its glycan structures is commonly found on the cell surface and widely participate in various physiological and pathological activities in both eukaryotic and prokaryotic organisms,including tissue development,cell adhesion,infection,inflammation and tumor metastasis.In tumor immunotherapy,the level of fucosylation of IgG-type antibodies is negatively correlated with antibody-dependent cell-mediated cytotoxicity(ADCC),so the lack of fucosylation has great potential in tumor immunotherapy.In terms of anti-infection,it has been shown that fucosylation modifications are closely related to microbial virulence and invasiveness,and the host can achieve immune defense by regulating fucosylation levels.This paper reviews the biosynthetic process of fucosylation and discusses its research and application in antitumor and infection immunity.关键词
翻译后修饰/岩藻糖基化/单糖Key words
Post-translational modification/Fucosylation/Monosaccharides引用本文复制引用
唐子涵,王艺霖,杨泽亮,李姗姗,逄宇..岩藻糖基化修饰在抗肿瘤和感染免疫中的研究进展[J].中国医学前沿杂志（电子版）,2026,18(3):18-24,7.基金项目
National Natural Science Foundation of China(82402638) （82402638）
Beijing Municipal Natural Science Foundation(7244295) 国家自然科学基金(82402638) （7244295）
北京市自然科学基金(7244295) （7244295）
