中国医学前沿杂志（电子版）2026，Vol.18Issue(3)：41-45,5.DOI:10.12037/YXQY.2026.03-06
基于分子分型的子宫内膜癌肿瘤免疫微环境
The tumor immune microenvironment of endometrial cancer based on molecular subtypes
摘要
Abstract
Endometrial cancer(EC)ranks among the three major gynecologic malignancies in women,with its incidence trending stages upward consistently on a global scale and the disease predominantly affecting postmenopausal women.Patients diagnosed at an early demonstrate relatively optimistic survival expectations,whereas those with advanced disease face concerning prognoses.Current therapeutic regimens encompass surgical resection,radiotherapy,chemotherapy,endocrine modulation and other modalities.For advanced,metastatic and recurrent cases,the options for adjuvant therapy are relatively limited.As an immunogenetic disease,the pathogenesis of endometrial cancer is profoundly regulated by the tumor immune microenvironment—a concept substantiated by numerous investigations.A finding that has been validated by numerous studies.At present,the molecular classification system has been established as the core criterion for EC subtyping,yet the characteristics of the tumor immune microenvironment corresponding to different molecular subtypes of EC remain to be elucidated.This paper systematically reviews the cutting-edge research findings on the tumor immune microenvironment characteristics of each molecular subtype of EC,with the aim of providing some assistance for clinical diagnosis and treatment of endometrial cancer.关键词
子宫内膜癌/分子分型/免疫微环境Key words
Endometrial cancer/Subtype/Immune microenvironment引用本文复制引用
孔蕊,张冲,王明,王志启,吴玉梅..基于分子分型的子宫内膜癌肿瘤免疫微环境[J].中国医学前沿杂志（电子版）,2026,18(3):41-45,5.基金项目
National Natural Science Foundation of China(82372957) （82372957）
Capital's Funds for Health Improvement and Research(2024-1-2112) 国家自然科学基金(82372957) （2024-1-2112）
首都卫生发展科研专项项目(首发2024-1-2112) （首发2024-1-2112）
