中国医学前沿杂志（电子版）2026，Vol.18Issue(4)：1-8,8.DOI:10.12037/YXQY.2026.04-01
成骨细胞葡萄糖代谢重编程研究进展
Research progresses on glucose metabolism reprogramming of osteoblasts
摘要
Abstract
Osteoblasts,as the core effector cells in bone tissue engineering,play a crucial role in bone development and homeostasis by mediating osteogenesis and mineralization of bone matrix.In recent years,an increasing number of studies have highlighted the critical interplay between energy metabolic reprogramming and bone formation,where glucose metabolism serves as a central energy pathway.Among them,glucose metabolism is the core pathway for providing energy to osteoblasts and their precursor cells.The activities of glycolysis,the tricarboxylic acid cycle,and oxidative phosphorylation critically regulate osteogenic differentiation and matrix.This article systematically reviews current advances in bone formation from the perspective of glucose metabolism:It examines the dynamic regulatory role of glucose uptake and catabolism in osteogenesis;analyzes the pathological physiological connection of the disruption of the"bone-energy"axis in metabolic disorders;and provides new ideas for precise intervention strategies for metabolism-associated osteoporosis.关键词
葡萄糖代谢/成骨细胞/骨质疏松Key words
Glucose metabolism/Osteoblast/Osteoporosis引用本文复制引用
潘琦,陈焕,楼媛,蔡青云,张丽娜,满富丽,段晓晔,郭立新..成骨细胞葡萄糖代谢重编程研究进展[J].中国医学前沿杂志（电子版）,2026,18(4):1-8,8.基金项目
Capital's Funds for Health Improvement and Research(2024-1-4053) 首都卫生发展科研专项(首发2024-1-4053) （2024-1-4053）
