中国医学前沿杂志（电子版）2026，Vol.18Issue(4)：9-16,8.DOI:10.12037/YXQY.2026.04-02
能量代谢与衰老的研究进展
Research progress in energy metabolism and aging
摘要
Abstract
Energy metabolism serves as the fundamental basis for sustaining life activities,with its dynamic changes being intrinsically linked to organismal aging.As age advances,the efficiency of energy metabolism progressively declines,accompanied by significant alterations in mitochondrial function,metabolic signaling pathways,and metabolite-mediated epigenetic modifications.This process further compromise cellular function,tissue homeostasis,and overall health,thereby driving the onset of aging and related diseases.Modulating energy metabolism has been shown to ameliorate glucose and lipid metabolism,enhance cellular autophagy and mitochondrial function,and reduce oxidative stress,thereby exerting anti-aging effects and mitigating aging-associated pathologies.Integrating emerging technologies to enable dynamic monitoring of energy metabolism and precise intervention in the aging process represents a pivotal direction for future research.关键词
能量代谢/衰老/线粒体功能/代谢信号通路/代谢调控Key words
Energy metabolism/Aging/Mitochondrial function/Metabolic signaling pathways/Metabolic regulation引用本文复制引用
陈施静,林夏鸿..能量代谢与衰老的研究进展[J].中国医学前沿杂志（电子版）,2026,18(4):9-16,8.基金项目
Guangdong Provincial Medical Research Fund Directed Projects(C2025101) （C2025101）
Shenzhen Science and Technology Innovation Committee Fund(JCYJ20240813150436048) （JCYJ20240813150436048）
Shenzhen Medical Research Special Fund(C2501002) 广东省医学科学技术研究基金项目指令性课题(C2025101) （C2501002）
深圳市科技计划资助(JCYJ20240813150436048) （JCYJ20240813150436048）
深圳市医学研究专项资金项目(C2501002) （C2501002）
