中国医学前沿杂志（电子版）2026，Vol.18Issue(4)：25-32,8.DOI:10.12037/YXQY.2026.04-04
代谢异常驱动的动脉粥样硬化神经-免疫调控机制及干预策略研究进展
Research progress on neuro-immune regulatory mechanisms and interventional strategies in metabolism-driven atherosclerosis
摘要
Abstract
There exists a bidirectional and plastic neuro-immune pathway between the vascular wall and the brain,known as the artery-brain circuit(ABC).The ABC is not only a sensory system by which blood vessels detect injury,but also a central driver that sustains inflammatory amplification and promotes vascular structural degeneration,with the capacity to continuously monitor vascular status and modulate local immune responses.Under conditions of metabolic dysregulation and chronic inflammation,a highly integrated dynamic circuit forms among neural,immune,and vascular cells,enabling local inflammatory signals to be rapidly intensified,remotely amplified,and ultimately leading to vascular functional decline.This review systematically summarizes the key mechanisms underlying neuro-immune-vascular coupling in metabolism-driven atherosclerosis,with a particular focus on the role of the artery-brain circuit(ABC)in inflammatory amplification,neural functional remodeling,and the progression of atherosclerosis.Furthermore,we highlight emerging interventional strategies targeting autonomic nervous regulation and neuro-immune pathways and discuss their translational application prospects.关键词
代谢异常/动脉粥样硬化/动脉-脑回路/神经-免疫调控Key words
Metabolic dysregulation/Atherosclerosis/Artery-brain circuit/Neuro-immune regulation引用本文复制引用
周丹,任惠霞,刘梅歌,谢娜娜,袁嘉雯,姜昕..代谢异常驱动的动脉粥样硬化神经-免疫调控机制及干预策略研究进展[J].中国医学前沿杂志（电子版）,2026,18(4):25-32,8.基金项目
Guangdong Medical Science and Technology Research Fund(A2025125) （A2025125）
Shenzhen Basic Research Program(JCYJ20240813103817024) 广东省医学科学技术研究基金(A2025125) （JCYJ20240813103817024）
深圳市基础研究专项基金(JCYJ20240813103817024) （JCYJ20240813103817024）
