中国癌症防治杂志2026，Vol.18Issue(2)：156-161,6.DOI:10.3969/j.issn.1674-5671.2026.02.04
卵巢固有韧带联合宫颈注射双示踪剂定位高危子宫内膜癌盆腔及腹主动脉旁前哨淋巴结的初步探究
Preliminary study on dual-tracer in high-risk endometrial cancer using proper ovarian ligament and cervical injections for pelvic and para-aortic sentinel lymph node mapping
摘要
Abstract
Objective To preliminarily investigate the feasibility and potential visualization value of dual-tracer for pelvic and para-aortic sentinel lymph node(SLN)mapping during laparoscopic surgery in patients with high-risk endometrial cancer.Methods This single-center,prospective observational study enrolled ten patients with high-risk endometrial cancer who underwent laparoscopic surgery at Guangxi Medical University Cancer Hospital between January 5,2025 and February 10,2026.All patients were classified as preoperative clinical stage of Ⅰ A-Ⅱ according to the 2009 FIGO staging system.The dual-tracer technique was performed,with indocyanine green(ICG)injected into the proper ovarian ligament and methylene blue injected into the cervix,to achieve regional mapping of pelvic and para-aortic SLN.The bilateral detection rates,anatomical locations,pathological results of pelvic and para-aortic SLN and perioperative complications were recorded.Results Dual-tracer SLN mapping was successfully completed in all 10 patients.The detection rates of right and left sides para-aortic SLN were 100%(10/10)and 90%(9/10),respectively,and the detection rates of right and left sides pelvic SLN were 80%(8/10)and 70%(7/10),respectively.Right sides para-aortic SLN were mainly located 2-3 cm above the right side of the aortic bifurcation,whereas left sides para-aortic SLN were mainly located between the inferior mesenteric artery and the area below the left renal vein.Pelvic SLN were mainly located in the medial external iliac region and the upper obturator region.Pathological examination revealed one case of isolated para-aortic lymph node metastasis,and one case with positive SLN in both pelvic and para-aortic regions.No postoperative complications such as lymphatic leakage occurred in any patient within 1 week after surgery.Conclusions The dual-tracer technique combining ICG injection into the proper ovarian ligament and methylene blue in-jection into cervical is clinically feasible and demonstrates promising visualization value for intraoperative mapping of pelvic and para-aortic SLN in patients with high-risk endometrial cancer.However,its diagnostic performance and clinical significance require fur-ther validation in large-sample studies.关键词
高危子宫内膜癌/双示踪剂/前哨淋巴结/卵巢固有韧带/腹主动脉旁淋巴结Key words
High-risk endometrial cancer/Dual-tracer/Sentinel lymph node/Proper ovarian ligament/Para-aortic lymph node分类
医药卫生引用本文复制引用
农艳瑾,韦有生,黄芳依,邵如玉,姚德生..卵巢固有韧带联合宫颈注射双示踪剂定位高危子宫内膜癌盆腔及腹主动脉旁前哨淋巴结的初步探究[J].中国癌症防治杂志,2026,18(2):156-161,6.基金项目
广西重点研发计划项目(桂科AB17292092) （桂科AB17292092）
广西南宁市青秀区重点研发计划项目(2021005) （2021005）
