中国癌症防治杂志2026，Vol.18Issue(2)：171-177,7.DOI:10.3969/j.issn.1674-5671.2026.02.06
中晚期结直肠癌患者抑郁与靶向治疗疗效及生活质量相关性的纵向研究
A longitudinal study on the correlation between depression and targeted therapy efficacy,and quality of life in patients with middle and advanced colorectal cancer
摘要
Abstract
Objective To explore the longitudinal correlation between depressive symptoms and therapy efficacy,and quality of life(QoL)in patients with middle and advanced colorectal cancer undergoing targeted therapy,and to provide clinical evidence for optimizing individualized treatment regimens and improving patient prognosis.Methods A prospective longitudinal study was conducted on patients with newly diagnosed middle and advanced colorectal cancer receiving targeted therapy at Guangxi Medical University Cancer Hospital from October 2024 to August 2025.Follow-up was performed at three time points:before the initiation of targeted therapy(T0),the 3rd month of treatment(T1),the 6th month of treatment(T2).Depressive symptoms were measured via the patient health questionnaire-9(PHQ-9),treatment efficacy was evaluated per the RECIST Version 1.1,and QoL was assessed using the functional assessment of cancer therapy-colorectal(FACT-C).Generalized estimating equations(GEE)and cross-lagged panel models were applied for longitudinal statistical analysis.Results A total of 140 patients completed the 6-month follow-up.The overall incidence of depression was 47.9%(67/140),showing high temporal stability.The objective response rate(ORR)was significantly higher in the non-depression group(54.8%)than in the depression group(28.4%,P=0.002).Multivariable regression showed that after controlling for confounding factors,the risk of not achieving ORR in depression group was 4.18 times that of the non-depression group(P=0.009).GEE analysis indicated a continuous decline in QoL for the depression group.At T2 period,the depression group showed a significantly greater magnitude of de-cline than the non-depression group for the total QoL score and all individual dimension scores including social/family well-being,emotional well-being,functional well-being and colorectal cancer-specific status(all P<0.001).Cross-lagged analysis further confirmed that the depression level at T1 could negatively predict QoL at T2(β=-0.189,P<0.001),while the reverse prediction was not statisti-cally significant.Conclusions Patients with advanced colorectal cancer receiving targeted therapy have a relatively high incidence of depression,and depression is closely associated with poorer ORR and continuous deterioration of QoL.关键词
结直肠癌/抑郁/靶向治疗/疗效/生活质量/纵向研究Key words
Colorectal cancer/Depression/Targeted therapy/Therapy efficacy/Quality of life/Longitudinal study分类
医药卫生引用本文复制引用
林秋华,李繁荣,赵凤娟,田玉麒,游雪梅..中晚期结直肠癌患者抑郁与靶向治疗疗效及生活质量相关性的纵向研究[J].中国癌症防治杂志,2026,18(2):171-177,7.基金项目
广西自然科学基金项目(2025GXNSFAA069616) （2025GXNSFAA069616）
