摘要
Abstract
Objective To investigate the levels and diagnostic value of serum Dectin-1,β-defensin-3(HBD-3),thymic stromal lymphopoietin(TSLP)in children with fungal rhino-sinusitis(FRS).Methods From May 2022 to March 2024,68 FRS children from the Handan First Hospital were selected as the case group,and another 68 non FRS children were selected as the control group.Another 45 children with FRS(FRS group)who were treated in the hospital from May 2024 to May 2025 and 45 children without FRS(non-FRS group)who received treatment were selected for external validation of the diagnostic model.ELISA method was applied to detect the expression levels of serum Dectin-1,HBD-3,and TSLP.Multivariate logistic regression was applied to analyze the relevant factors affecting the occurrence of FRS.ROC curve was applied to analyze the diagnostic value of serum Dectin-1,HBD-3,and TSLP levels for FRS.Results The C-reactive protein white blood cell count,neutrophil percentage,serum Dectin-1,TSLP levels in the case group were obviously higher than those in the control group,while serum HBD-3 level was obviously lower than that in the control group(P<0.05).Serum Dectin-1,HBD-3,TSLP,C-reactive protein,white blood cell count,and neutrophil percentage were related factors affecting the occurrence of FRS(P<0.05);the area under the curve(AUC)of the combination of serum Dectin-1,HBD-3,and TSLP in the diagnosis of FRS was 0.949,which was better than their respective single diagnoses(Z triple combination-Dectin-1=3.853,Z triple combination-HBD-3=3.116,Z triple combination-TSLP=3.512,P<0.001,P=0.002,P<0.001),the sensitivity and specificity of the combined diagnosis were 88.24％and 89.71％,respectively.The AUC of the combined diagnostic model of the three in external validation was 0.945,with a sensitivity of 91.11％and a specificity of 84.44％.Conclusion Serum Dectin-1 and TSLP levels are obviously elevated in children with FRS,while serum HBD-3 level is obviously decreased.The combination of the three has higher diagnostic value for the occurrence of FRS.关键词
真菌性鼻窦炎/C型凝集素-1/β-防御素-3/胸腺基质淋巴细胞生成素/诊断价值Key words
fungal rhino-sinusitis/Dectin-1/β-defensin-3/thymic stromal lymphopoietin/diagnostic value
