中国肿瘤生物治疗杂志2026，Vol.33Issue(4)：351-362,12.DOI:10.3872/j.issn.1007-385x.2026.04.001
口腔微生物与结直肠癌:作用机制及治疗策略
Oral microbiota and colorectal cancer:mechanisms and therapeutic strategies
摘要
Abstract
Colorectal cancer(CRC),a malignant tumor,is a leading cause of cancer-related morbidity and mortality worldwide.Accumulating evidence suggests that CRC occurrence and development are closely associated not only with intestinal microbiota dysbiosis,but also with oral microbiota.Specific oral microbes can translocate via the oral-gut axis to colonize the intestinal tract and distant tumor sites.Through mechanisms such as adhesion and colonization,activation of oncogenic signaling pathways,enhancement of tumor cell migration and invasion,and remodeling of the tumor microenvironment,these microbes promote tumor progression and may influence responses to anticancer therapies.These findings highlight the potential of targeting oral microbiota in CRC clinical management.This review systematically summarizes the molecular mechanisms by which oral microbiota contributes to CRC pathogenesis,with a particular focus on microbial intervention strategies that target the oral-gut axis.This review also discusses current research limitations and future directions,aiming to provide a reference for both basic research and clinical translation in this field.关键词
口腔微生物/结直肠癌/作用机制/治疗策略Key words
oral microbiota/colorectal cancer(CRC)/mechanism/therapeutic strategy分类
医药卫生引用本文复制引用
张仁怡,由凤鸣,李雪珂..口腔微生物与结直肠癌:作用机制及治疗策略[J].中国肿瘤生物治疗杂志,2026,33(4):351-362,12.基金项目
国家自然科学基金(82505494) （82505494）
成都市卫生健康委员会成都中医药大学委校联合创新基金(WXLH202403144) （WXLH202403144）
