中国中西医结合影像学杂志2026，Vol.24Issue(3)：268-272,5.DOI:10.3969/j.issn.1672-0512.2026.03.002
Sonazoid超声造影与MRI增强扫描诊断肝硬化背景下最大径≤3 cm肝细胞癌的对比研究
A comparative study of Sonazoid contrast-enhanced ultrasound and contrast-enhanced MRI in diagnosis of hepatocellular carcinoma with a maximum diameter of≤3 cm in liver cirrhosis
摘要
Abstract
Objective:To analyze the diagnostic efficacy of Sonazoid contrast-enhanced ultrasound and contrast-enhanced MRI in hepatocellular carcinoma with a maximum diameter of≤3 cm in patients with liver cirrhosis,and to provide a reference for clinical diagnosis and treatment.Methods:A total of 55 patients with intrahepatic space-occupying lesions in the background of liver cirrhosis were selected,with a total of 62 lesions,the maximum diameter of which was≤3.0 cm.Among them,40 lesions were hepatocellular carcinomas(malignant group),and 22 were benign lesions(benign group).All patients underwent Sonazoid contrast-enhanced ultrasound and contrast-enhanced MRI examinations.The results of histopathology or clinical follow-up were taken as the gold standard.The accuracy,sensitivity,and specificity of Sonazoid contrast-enhanced ultrasound and contrast-enhanced MRI in diagnosing hepatocellular carcinomas with a maximum diameter of≤3 cm were compared,and the diagnostic consistency of the two methods was analyzed.Results:Sonazoid contrast-enhanced ultrasound showed that in the malignant group,the lesions presented mainly with high enhancement during the arterial phase,equal or low enhancement during the portal vein and delayed phases,and low enhancement during the Kupffer phase,while in the benign group,the lesions presented mainly with high enhancement during the arterial phase,and equal enhancement during the portal vein phase,delayed phase and Kupffer phase.The comparison of enhancement characteristics in each phase between the two groups showed statistically significant differences(all P<0.01).The accuracy,sensitivity and specificity of Sonazoid contrast-enhanced ultrasound in diagnosing hepatocellular carcinoma were 93.5%(58/62),92.5%(37/40),and 95.5%(21/22),respectively,while those of contrast-enhanced MRI were 91.9%(57/62),95.0%(38/40),and 86.4%(19/22),and the differences were not statistically significant(all P>0.05),and the consistency of the two methods in diagnosing hepatocellular carcinoma was high(K=0.93).Conclusions:The diagnostic efficacy of Sonazoid contrast-enhanced ultrasound and contrast-enhanced MRI for hepatocellular carcinoma with a maximum diameter of≤3 cm in patients with liver cirrhosis is similar,and both have high clinical application value.关键词
超声造影/Sonazoid/磁共振成像/肝硬化/癌,肝细胞Key words
Contrast-enhanced ultrasound/Sonazoid/Magnetic resonance imaging/Liver cirrhosis/Carcinoma,hepatocellular分类
医药卫生引用本文复制引用
高志玲,袁杰,何峥,梅和平,雷洁雯,陈薇,李胜,吴凡,高月求,黄凌鹰,朱晓骏..Sonazoid超声造影与MRI增强扫描诊断肝硬化背景下最大径≤3 cm肝细胞癌的对比研究[J].中国中西医结合影像学杂志,2026,24(3):268-272,5.基金项目
上海中医药大学预算内项目(2021LK086). （2021LK086）
