中国中医基础医学杂志2026，Vol.32Issue(5)：953-956,4.
基于"肾脆"理论探析糖尿病肾脏疾病病机特点
Analysis of Pathogenesis Characteristics of Diabetic Kidney Disease Based on the"Kidney Fragility"Theory
摘要
Abstract
Guided by the theory of"kidney fragility",this study posits that inherent kidney fragility or the loss of renal dynamic equilibrium constitutes the core internal factor in the pathogenesis of diabetic kidney disease(DKD)."Kidney Fragility"encompasses not only generalized kidney deficiency but also emphasizes the inherent vulnerability and imbalance in the kidney's structural and functional microenvironment.This fragility predisposes the kidneys to greater susceptibility,earlier onset,and more severe damage under comparable pathological insults.The pathogenesis initiates with"stagnation of the dual Yang"triggering"kidney fragility",followed by the downward flow of internal heat and turbid toxins to the lower burner.This process progressively evolves into essence depletion,Qi exhaustion,and collateral impairment,ultimately leading to the formation of concretions within the kidney collaterals.In clinical practice,individualized treatment strategies should be formulated based on the distinct pathological characteristics at different disease stages and the specific constitutional types of kidney fragility,thereby providing theoretical guidance for the precision prevention and management of DKD.关键词
糖尿病肾脏疾病/肾脆/内热致癥/个体化/病机特点Key words
Diabetic kidney disease/Kidney fragility/Internal heat leading to concretions/Individuation/Pathogenesis characteristics分类
医药卫生引用本文复制引用
李垚锬,侯金易,蔡雨孜,孙卫卫,郑慧娟,张兴华,吴霄畅,刘伟敬,王耀献..基于"肾脆"理论探析糖尿病肾脏疾病病机特点[J].中国中医基础医学杂志,2026,32(5):953-956,4.基金项目
国家中医药管理局重点学科建设项目-北京中医药大学中医肾病学(zyyzdxk-2023260) （zyyzdxk-2023260）
国家中医药管理局中医药传承与创新"百千万"人才工程(岐黄学者-国家中医药领军人才支持计划)(国中医药人教发[2018]12号) （岐黄学者-国家中医药领军人才支持计划）
