中国中医基础医学杂志2026，Vol.32Issue(5)：962-965,4.
基于"瘀毒损神、枢机不利"的形神共病观论治卒中后抑郁
Treatment of Post-Stroke Depression Based on the Concept of"Form-Spirit Co-Morbidity"Under the Theory of"Stasis-Toxin Damaging the Spirit and Impairment of Pivotal Function"
摘要
Abstract
Post-stroke depression(PSD)is a typical manifestation of form-spirit co-morbidity after stroke.Its high incidence and severe disability significantly hinder patient recovery and reduce quality of life.Based on the traditional Chinese medicine(TCM)theory of"form-spirit co-morbidity",this paper proposes the core pathogenesis hypothesis of"stasis-toxin damaging the spirit and impairment of pivotal function"in PSD:endogenous stasis-toxin serves as the pathological basis of form-spirit co-morbidity,impairment of pivotal function is the key link in the disharmony between form and spirit,and damage to the spirit-orifice constitutes the core mechanism of depressive manifestations.These three factors interact to form a vicious cycle,driving disease progression.Based on this pathogenesis,a TCM therapeutic system of"detoxifying and resolving stasis,regulating and smoothing pivotal function,and calming the spirit and stabilizing the mind"is established.This not only provides scientific support for TCM diagnosis and treatment of PSD but also offers new theoretical perspectives and practical approaches for its clinical management.关键词
卒中后抑郁/瘀毒损神/枢机不利/形神共病/中医病机Key words
Post-stroke depression/Stasis-toxin damaging the spirit/Impairment of pivotal function/Form-spirit co-morbidity/TCM pathogenesis分类
医药卫生引用本文复制引用
金霞霞,贾媛媛,吕昕,侯强,李涛,闫咏梅,唐志书,王高峰,王晓峰,董秦川,李丽娜,刘金榜,王秋茹,张勇,张锦..基于"瘀毒损神、枢机不利"的形神共病观论治卒中后抑郁[J].中国中医基础医学杂志,2026,32(5):962-965,4.基金项目
陕西省中医药管理局中医药科研专项资金项目(2025年) （2025年）
国家自然科学基金项目(82274107) （82274107）
国家岐黄学者支持项目(2022年) （2022年）
高水平重点学科项目(2024年) （2024年）
