摘要
Abstract
Objective:To investigate the improving effects of edaravone dexborneol combined with tirofiban on cerebral hemodynamics,oxidative stress and vascular endothelial function in patients with acute cerebral infarction(ACI).Methods:A total of 114 ACI patients admitted to our hospital from January 2023 to December 2024 were retrospectively enrolled and divided into control group(treated with tirofiban)and study group(treated with edaravone dexborneol combined with tirofiban)according to treatment regimens,with 57 cases in each group.Oxidative stress indicators,cerebral hemodynamics indicators,vascular endothelial function indicators,neurological function indicators,daily living ability indicators,clinical efficacy and adverse reactions were compared between the two groups.Results:Repeated measurement analysis showed that there were statistically significant differences in time-point,inter-group and interaction effects of malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),peripheral resistance(PR),mean blood flow velocity(Vmean),cerebrovascular resistance(CVR),thromboxane A2(TXA2),endothelin-1(ET-1),angiopoietin-1(ANG-1),Barthel index(BI)and National Institutes of Health Stroke Scale(NIHSS)score between the two groups(P<0.05).After 1 and 2 weeks of treatment,the levels of MDA,PR,CVR,TXA2,ET-1,ANG-1,and NIHSS scores decreased in both groups,and the study group showed lower values than the control group(P<0.05),and those in the study group were lower than those in the control group(P<0.05);SOD,GSH-Px,and BI score were increased,and those in the study group were higher than those in the control group(P<0.05);Vmean was increased,and that in the study group was faster than the control group(P<0.05).The total clinical effective rate of the study group was higher than that of the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Edaravone dexborneol combined with tirofiban can significantly improve cerebral hemodynamics,reduce oxidative stress and protect vascular endothelial function in patients with ACI,without increasing adverse reactions.关键词
依达拉奉右莰醇/替罗非班/急性脑梗死/脑血流动力学/氧化应激/血管内皮功能Key words
edaravone dexborneol/tirofiban/acute cerebral infarction/cerebral hemodynamics/oxidative stress/vascular endothelial function分类
医药卫生
