中华骨质疏松和骨矿盐疾病杂志2026，Vol.19Issue(1)：65-73,9.DOI:10.3969/j.issn.1674-2591.2026.01.008
基于两样本双向孟德尔随机化的甲状腺功能亢进症和骨质疏松症因果关系研究
Causal relationship between hyperthyroidism and osteoporosis:based on two-sample bidirectional Mendelian randomization
摘要
Abstract
Objective To evaluate the causal relationship between hyperthyroidism and osteoporosis using a two-sample bidirectional Mendelian randomization(MR)approach.Methods Large-scale genome-wide association study(GWAS)data from European populations were used.Hyperthyroidism summary statistics were obtained from the UK Biobank(GWAS ID:UKB-B-20289,n=462 933,2018)and osteoporosis data were derived from the European Bioinfor-matics Institute(EBI)GWAS database(GWAS ID:ebi-a-GCST90038656,n=484 598,2021).Statistical analysis was performed using R software(version 4.4.0).The inverse variance weighted(IVW)method served as the primary analyti-cal approach,supplemented by MR-Egger regression,weighted median and other complementary MR methods.Reverse MR analysis was conducted to exclude potential reverse causality.Heterogeneity,sensitivity and horizontal pleiotropy ana-lyses were further performed to ensure the robustness of the findings.Results Forward MR analysis showed that hyperthy-roidism significantly increased the risk of osteoporosis(IVW:OR=1.158,95%CI:1.050-1.277,P=0.0033),and the results were consistent across different MR methods.The MR-Egger intercept was not statistically significant(P=0.837),indicating no substantial horizontal pleiotropy.Reverse MR analysis demonstrated no significant causal effect of osteoporosis on hyperthyroidism(IVW:OR=1.028,95%CI:0.976-1.083,P=0.292)and sensitivity analyses showed no notable abnormalities.Conclusion Hyperthyroidism can increase the risk of osteoporosis,while osteoporosis exerts no reverse causal effect on hyperthyroidism.Future research can combine metabolomics and molecular mechanism studies to further clarify its biological basis,thereby providing a reference for the prevention and management of osteoporosis.关键词
甲状腺功能亢进症/骨质疏松症/孟德尔随机化/因果推断/基因多态性Key words
hyperthyroidism/osteoporosis/Mendelian randomization/causal inference/genetic polymorphism分类
医药卫生引用本文复制引用
侯佳林,胡聪婷,林鑫淼,蔡加琴..基于两样本双向孟德尔随机化的甲状腺功能亢进症和骨质疏松症因果关系研究[J].中华骨质疏松和骨矿盐疾病杂志,2026,19(1):65-73,9.基金项目
福建省自然科学基金(2023J011207) （2023J011207）
