中成药2026，Vol.48Issue(4)：1069-1078,10.DOI:10.3969/j.issn.1001-1528.2026.04.001
桃红四物汤化学成分分析及活性组分含量测定
Analysis of chemical constituents and content determination of active components for Taohong Siwu Decoction
摘要
Abstract
AIM To analyze the chemical constituents in Taohong Siwu Decoction,and to determine the contents of active components.METHODS HPLC-LTQ-Orbitrap MS was adopted in the qualitative analysis,HPLC-MS/MS was adopted in the content determination of paeoniflorin,amygdalin,hydroxysafflower yellow A,ferulic acid,ligustilide,catalpol,verbascoside,kaempferol,albiflorin,benzoylpaeoniflorin,senkyunolide I,senkyunolide A,butylphthalide,5-hydroxymethylfurfural,coumaric acid,gallic acid,caffeic acid and catechins.RESULTS Total 102 constituents were identified,containing 14 phthalides,23 flavonoids,17 organic acids,27 glycosides,8 amino acids,and 13 others.Eighteen active components showed good linear relationships within their own ranges(r＞0.999 0),whose average recoveries were 70.02%-120.49%with the RSDs of 1.65%-4.54%,among which the contents of paeoniflorin(4.675%-5.403%),amygdalin(1.353%-1.512%)and senkyunolide A(1.317%-2.813%)were high,while those of others were 0.001%-0.947%.CONCLUSION This stable and reliable method can be used for the quality control of Taohong Siwu Decoction.关键词
桃红四物汤/化学成分/活性组分/定性分析/含量测定/HPLC-LTQ-Orbitrap MS/HPLC-MS/MSKey words
Taohong Siwu Decoction/chemical constituents/active components/qualitative analysis/content determination/HPLC-LTQ-Orbitrap MS/HPLC-MS/MS分类
医药卫生引用本文复制引用
常昊,唐林峰,赵梦蝶,李金淼,李涛,韩岚..桃红四物汤化学成分分析及活性组分含量测定[J].中成药,2026,48(4):1069-1078,10.基金项目
国家自然科学基金(82074152) （82074152）
