中国兽药杂志2026，Vol.60Issue(4)：7-17,11.DOI:10.11751/ISSN.1002-1280.2026.4.02
C(9)-奥美拉唑小檗碱衍生物在异育银鲫组织中的分布与药代动力学研究
Distribution and Pharmacokinetic Study of C(9)-Omeprazole Berberine Derivatives in Carassius auratus gibebio Tissues
摘要
Abstract
This study investigated the tissue distribution and pharmacokinetic characteristics of a C(9)-berberine derivative substituted with an omeprazole moiety in Carassius auratus gibelio.A single intraperitoneal injection was administered at a dose of 1.5 mg/kg.Bile,liver,intestine,spleen,muscle,kidney,eye,and brain tissues were collected between 3 and 360 hours post-administration.Drug concentrations in these tissues were determined using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(HPLC-Q-TOF/MS).Key pharmacokinetic parameters were calculated based on non-compartmental analysis(NCA)using PK Solver software.The results revealed significant differences in the distribution and elimination of the derivative across tissues.The highest concentration was observed in bile(Cmax=2161.5±218.7 ng/g),followed by the liver(700.60±42.4 ng/g)and intestine(500.50±25.2 ng/g),while relatively low residual levels were detected in edible tissues such as muscle.Pharmacokinetic parameters indicated prolonged retention in bile,liver,and intestine,with mean residence times(MRT)of 120.92 h,130.62 h,and 67.72 h,respectively;terminal half-lives(T1/2)of 96.43 h,94.38 h,and 52.24 h;and areas under the curve(AUC0-inf)of 112777.30,61711.70,and25706.62 ng·h/g,respectively.The longest T1/2 values were found intheeye(206.43 h)andbrain(201.13 h),with MRT0-infvaluesof341.02 hand329.36 h,suggesting slow elimination from these tissues.In conclusion,the C(9)-omeprazole berberine derivative is rapidly absorbed,widely distributed in metabolic and target organs,and exhibits prolonged retention in Carassius auratus gibelio,supporting its potential as an antibacterial and antiviral agent for aquaculture applications.关键词
小檗碱衍生物/异育银鲫/组织分布/药代动力学/HPLC-Q-TOF/MS/非房室模型Key words
berberine derivative/Carassius auratus gibelio/tissue distribution/pharmacokinetics/HPLC-Q-TOF/MS/non-compartmental analysis分类
农业科技引用本文复制引用
张帅,杨乐,敖大,岳纹龙,王宇翔,滕巧巧,孟启,蔡志强..C(9)-奥美拉唑小檗碱衍生物在异育银鲫组织中的分布与药代动力学研究[J].中国兽药杂志,2026,60(4):7-17,11.基金项目
常州大学高层次人才引进项目(ZMF23020214) （ZMF23020214）
