中国兽药杂志2026，Vol.60Issue(4)：18-25,8.DOI:10.11751/ISSN.1002-1280.2026.4.03
阿福拉纳的合成工艺研究
Study on the Synthesis Process of Afoxolaner
摘要
Abstract
Afoxolaner is a long-lasting oral and topical antiparasitic drug with rapid efficacy and high safety characteristics.In this article,A synthetic method suitable for industrial afoxolaner was studied.Intermediate 1of afoxolaner was was prepared by using 4-phenylpropiophenone and 2,2,2-trifluoroacetophenone as starting materials at temperatures between 75~80℃;Intermediate 1 of afoxolaner was dehydrated and cyclized to gave Intermediate 3,following being condensed with 2-amino-N-trifluoroethylacetamide to gave afoxolaner.The process technology was suitable for industrial afoxolaner withreadily available,inexpensive material and high content of products.关键词
4-乙酰基萘甲酸/2-氨基-N-(2,2,2-三氟乙基)乙酰胺/缩合/阿福拉纳Key words
4-acetylnaphthalic acid/2-amino-N-(2,2,2-trifluoroethyl)acetamide/condensation/Afoxolaner分类
农业科技引用本文复制引用
章安源,李志远,马居良,刘性伟,李松励,郑真真,马然,李有志..阿福拉纳的合成工艺研究[J].中国兽药杂志,2026,60(4):18-25,8.基金项目
山东省重大科技创新工程项目:家禽重要疫病防控与新药创制(2025CXGC010803) （2025CXGC010803）
