中国猪业2026，Vol.21Issue(2)：31-39,9.DOI:10.16174/j.issn.1673-4645.2026.02.004
PRRSV Nsp1β与Nsp2免疫逃逸及毒力演化的研究进展
Research progress on immune escape and virulence evolution of PRRSV Nsp1β and Nsp2
摘要
Abstract
Porcine reproductive and respiratory syndrome virus is an important pathogen that endangers the global swine industry,the pathogenic core of this virus lies in the strong immune evasion and replication regulation mediated by its encoded non-structural proteins.The PRRSV non-structural protein family has many members,Nsp1β and Nsp2 play a key role in innate immune suppression,regulation of viral virulence,and genetic variation evolution.This article systematically clarified the molecular mechanism by which PRRSV Nsp1β targets host genes and blocks innate immune signaling pathways.It focused on analyzing the genetic and variant characteristics of Nsp2 at the molecular level and the host factor antagonistic patterns at the protein level,and the differences functions of the Nsp2 in different PRRSV strain.Summarized the weak links in current research and clarify future directions,aiming to provide theoretical support for the pathogenesis of PRRSV,the development of new vaccines,and the screening of antiviral drugs.关键词
PRRSV/非结构蛋白/Nsp1β/Nsp2/免疫逃逸/毒力调控/遗传变异Key words
PRRSV/non-structural proteins/Nsp1β/Nsp2/immune evasion/virulence regulation/genetic variance分类
农业科技引用本文复制引用
朱广琴,倪俊芬,刘真..PRRSV Nsp1β与Nsp2免疫逃逸及毒力演化的研究进展[J].中国猪业,2026,21(2):31-39,9.基金项目
江苏省职业教育现代养殖技术双师型名师工作建设项目 （）
中国农业科学院基本科研业务费专项(Y2024JC36) （Y2024JC36）
江苏现代农业产业技术体系建设项目(JATS[2023]053) （JATS[2023]053）
