中国猪业2026，Vol.21Issue(2)：55-63,9.DOI:10.16174/j.issn.1673-4645.2026.02.006
胆汁酸调控断奶仔猪肠道功能的研究进展与机制
Research progress and mechanisms of bile acids in regulating intestinal function in weaned piglets
摘要
Abstract
Bile acids play a crucial role in maintaining lipid metabolism and intestinal homeostasis in weaned piglets,yet their systematic mechanisms in alleviating weaning stress remain to be fully elucidated.This review systematically analyzed the effects of weaning stress on intestinal barrier function,microbiota and immune responses in piglets.It highlights the role of bile acids as signaling molecules in activating receptors such as the farnesoid X receptor and G protein-coupled bile acid receptor 5,thereby regulating signaling pathways including myosin light chain kinase and phosphatidylinositol 3-kinase/protein kinase B.These mechanisms increase expression of tight junction proteins,improve villus morphology,modulate immune function,and stabilize gut microbiota.The review also summarized the beneficial effects of dietary bile acid supplementation on increasing average daily gain,reducing diarrhea rate,and promoting intestinal development in weaned piglets.Finally,future research directions were proposed to further explore bile acids as a nutritional intervention strategy,provide a theoretical basis for mitigating weaning stress and ensuring intestinal health in piglets.关键词
猪/胆汁酸/断奶仔猪/肠道屏障/肠道微生物/免疫调节Key words
pjg/bile acids/weaned piglets/intestinal barrier/gut microbiota/immune regulation分类
农业科技引用本文复制引用
王依如,王腾飞,王伟,柏峻,李忻航,李新建,乔瑞敏,韩雪蕾,王克君,李秀领,杨峰,余彤..胆汁酸调控断奶仔猪肠道功能的研究进展与机制[J].中国猪业,2026,21(2):55-63,9.基金项目
河南省高等学校重点科研项目(26B230003) （26B230003）
中国博士后科学基金第77批面上资助项目(2025M770253) （2025M770253）
河南省自然科学基金项目(青年基金项目) （青年基金项目）
