转化医学杂志2026，Vol.15Issue(5)：747-751,5.DOI:10.3639/j.issn.2095-3097.2026.05.005
血清肺表面活性蛋白D和脂多糖结合蛋白对呼吸机相关性肺炎患者短期内撤机的预测价值
Predictive Value of Serum Surfactant Protein D and Lipopolysaccharide-Binding Protein for Short-Term Weaning in Patients with Ventilator-Associated Pneumonia
摘要
Abstract
Objective To explore the predictive value of serum pulmonary surfactant protein D(SP-D)and lipopolysaccharide binding protein(LBP)levels for short-term successful weaning in patients with ventilator-associated pneumonia(VAP).Methods A retrospective study was conducted on 172 patients with VAP admitted to the Eighth People's Hospital of Hebei Province from June 2022 to June 2025.The patients were divided into a successful weaning group(104 cases)and a failed weaning group(68 cases)based on the weaning outcome within 7 days.Venous blood was collected from all patients within 24 hours after the diagnosis of VAP,and serum SP-D and LBP levels were measured.The serum levels of SP-D and LBP and clinical data were compared between the two groups.The predictive efficacy of serum SP-D and LBP levels for short-term successful weaning in patients with VAP was analyzed using the receiver operating characteristic curve.Multivariate logistic regression analysis was used to identify the influencing factors for short-term successful weaning in patients with VAP.Results The serum levels of SP-D and LBP in the failed weaning group were higher than those in the successful weaning group(P<0.05).The area under the curve(AUC)of serum SP-D and LBP for predicting short-term successful weaning in patients with VAP was 0.731(95%CI:0.686-0.781)and 0.798(95%CI:0.753-0.848),respectively,and the AUC of their combined prediction was 0.902(95%CI:0.857-0.952).The failed weaning group had longer ICU stay and mechanical ventilation time,and higher proportions of patients with diabetes and smoking history than the successful weaning group(P<0.05).Multivariate logistic regression analysis showed that ICU stay(OR=1.857,95%CI:1.083-3.184),mechanical ventilation time(OR=2.079,95%CI:1.070-4.041),serum SP-D(OR=2.606,95%CI:1.717-3.957),and serum LBP(OR=2.649,95%CI:1.776-3.950)were independent influencing factors for short-term successful weaning in patients with VAP(P<0.05).Conclusion Serum SP-D and LBP can serve as effective biological indicators for predicting short-term weaning outcomes in patients with VAP,and their combined application may help improve the predictive efficacy.关键词
肺炎,呼吸机相关性/肺表面活性蛋白D/脂多糖结合蛋白/预测Key words
pneumonia,ventilator-associated/surfactant protein D/lipopolysaccharide-binding protein/prognosis引用本文复制引用
崔雪琴,焦红蕾,李红敏,柳宁,刘影,赵博雅,田利红..血清肺表面活性蛋白D和脂多糖结合蛋白对呼吸机相关性肺炎患者短期内撤机的预测价值[J].转化医学杂志,2026,15(5):747-751,5.基金项目
河北省中医药管理局科研计划项目(2025361) （2025361）
