浙江医学2026，Vol.48Issue(9)：908-913,6.DOI:10.12056/j.issn.1006-2785.2026.48.9.2025-1246
肾透析患者血清HIF-2α、RBP4水平变化及对动静脉内瘘功能障碍的预测价值
Serum HIF-2α and RBP4 levels and their predictive value for arteriovenous fistula dysfunction in hemodialysis patients
摘要
Abstract
Objective To investigate the serum levels of hypoxia inducible factor-2α(HIF-2α)and retinol binding protein 4(RBP4)in hemodialysis patients and their predictive value for arteriovenous fistula(AVF)dysfunction.Methods A total of 150 hemodialysis patients treated at the Chongqing Medical University Affiliated Liangjiang Hospital from January 2022 to December 2023 were retrospectively enrolled(hemodialysis group).Seventy-five healthy volunteers who underwent physical examination during the same period were included as the control group.Serum HIF-2α and RBP4 levels were measured using enzyme-linked immunosorbent assay.Multivariate logistic regression analysis was performed to identify risk factors for AVF dysfunction of hemodialysis patients.ROC curves were constructed to assess the predictive value of HIF-2α and RBP4 levels for their AVF dysfunction.Based on ROC-derived cutoff values,patients were divided into high-and low-level groups for serum HIF-2α and RBP4,and Kaplan-Meier analysis was performed to compare survival of patients in different level groups.Results Serum HIF-2α and RBP4 levels were significantly higher in the hemodialysis group than in the control group(all P＜0.05).During one-year follow-up,AVF dysfunction occurred in 55 of 150 hemodialysis patients,with an incidence of 36.67％.Diabetes,high HIF-2α and high RBP4 levels were identified as independent risk factors for AVF dysfunction of hemodialysis patients(all P＜0.05).The AUC of combined serum HIF-2α and RBP4 levels in predicting AVF dysfunction of hemodialysis patients was 0.884,which was higher than that of serum HIF-2α(0.812)or RBP4(0.783)alone(all P＜0.05).The one-year AVF dysfunction-free survival rate was lower in the high HIF-2α level and high RBP4 level groups compared with their low-level groups(all P＜0.05).Conclusion Elevated serum HIF-2α and RBP4 levels are closely associated with AVF dysfunction in hemodialysis patients.Combined detection of HIF-2α and RBP4 provides a higher predictive value for AVF dysfunction.关键词
肾透析/缺氧诱导因子-2α/视黄醇结合蛋白4/动静脉内瘘功能障碍Key words
Hemodialysis/Hypoxia-inducible factor-2α/Retinol binding protein 4/Arteriovenous fistula dysfunction引用本文复制引用
蓝燕青,丁瑜,罗琼,唐茂,陈纯娟..肾透析患者血清HIF-2α、RBP4水平变化及对动静脉内瘘功能障碍的预测价值[J].浙江医学,2026,48(9):908-913,6.基金项目
重庆市自然科学基金资助项目(cstc2021jcyj-msxmX0857) （cstc2021jcyj-msxmX0857）
