摘要
Abstract
Objective To systematically review existing literature and analyze the effect of botulinum toxin type A(BTA)injection on scar improvement after cleft lip repair(CLR).Methods Following the Preferred Reporting Items for Systematic Review and Meta-Analyses(PRISMA)guidelines,a systematic literature search was conducted in PubMed,Embase,Scopus,Web of Science,and the Cochrane Library.The search period was up to December 2025.A combination of MeSH terms and free-text words was used,with"botulinum toxin""cleft lip"and"scar"as keywords to construct the search strategy.Two investigators independently performed literature screening,data extraction,and risk of bias assessment;disagreements were resolved through discussion or arbitration by a third party.The primary outcome measures included Visual Analogue Scale(VAS)score,Vancouver Scar Scale(VSS)score,scar width,and complications related to BTA or CLR.Results A total of 5 studies(216 patients)met the inclusion criteria.Four studies focused on primary CLR during infancy,and one study included older patients requiring CLR.All patients received BTA injection into the orbicularis oris muscle(dose range:1-2 U/kg),with one study additionally injecting into the perioral muscles.All four studies that assessed scar width included a normal saline(0.9％sodium chloride injection)control group,and showed significantly reduced scar width in the BTA group.Among the five studies,three and two reported that BTA injection improved VAS and VSS scores,respectively.No BTA-or CLR-related complications were reported.Conclusion Current evidence supports that BTA injection can improve scar after CLR with a low risk of complications;future studies with larger sample sizes are warranted for further validation.关键词
A型肉毒毒素/唇裂修复术/瘢痕/唇裂/伤口愈合Key words
Botulinum toxin type A/Cleft lip repair/Scar/Cleft lip/Wound healing
