肿瘤防治研究2026，Vol.53Issue(5)：349-359,11.DOI:10.3971/j.issn.1000-8578.2026.25.0831
卵巢癌术后患者合并抑郁的影响因素
Influencing Factors of Depression in Patients with Postoperative Ovarian Cancer
摘要
Abstract
Objective To explore the prevalence of depressive symptoms in postoperative patients with ovarian cancer and to analyze its influencing factors from multiple dimensions,including clinical characteristics,psychological factors,and laboratory indicators.Methods A cross-sectional study was conducted,which enrolled 235 postoperative patients with ovarian cancer.Depressive status was assessed using the patient health questionnaire,and the demographic,pathological,and medical record data of the patients were collected using the generalized anxiety disorder scale,Pittsburgh sleep quality index,European organization for research and treatment of cancer quality of life questionnaire core 30,and ECOG performance status score.Peripheral blood tumor marker(CA125),routine blood test,lymphocyte subsets,and serum cytokine levels were measured.Univariate and multivariate binary logistic regression analysis were used for statistical analysis.Results The prevalence of depression in postoperative patients with ovarian cancer was 39.15%(92/235).Univariate analysis showed that ECOG score≥2 points,pain,anxiety,poor sleep quality,low quality of life,low life satisfaction,tumor recurrence,six or more cycles of chemotherapy,as well as higher levels of CA125,NLR,and NAR,and lower hemoglobin levels were significantly associated with depression(all P<0.05).Multivariate binary Logistic regression analysis showed that anxiety(OR=1.975,95%CI:1.231-3.170),sleep efficiency(OR=4.181,95%CI:1.211-14.43),sleep latency(OR=34.806,95%CI:4.258-284.542),ECOG performance status score,cognitive function(OR=0.918,95%CI:0.868-0.97),and life satisfaction were independent risk factors for depression(all P<0.05).Laboratory indicators were not independent influencing factors in the multivariate Logistic regression model.Conclusion Depression in postoperative patients with ovarian cancer is influenced by physiological,psychological,and social factors.Clinical management should focus on patients with anxiety,sleep disorders,poor physical condition,and low life satisfaction,and a comprehensive prevention and treatment strategy centered on psychological intervention and taking into account symptom management and social support should be implemented.关键词
卵巢癌/肿瘤相关性抑郁/心理神经症状群/睡眠障碍Key words
Ovarian cancer/Cancer-related depression/Psychoneurotic sym-ptom cluster/Sleep disorder分类
医药卫生引用本文复制引用
姚嘉良,陆鑫熠,于盼,从恩朝,张龙,田建辉,刘泽,杨蕴,周奕阳,李明花,姚望,史文斐..卵巢癌术后患者合并抑郁的影响因素[J].肿瘤防治研究,2026,53(5):349-359,11.基金项目
四大慢病重大专项(2024ZD0521402) （2024ZD0521402）
上海市科学技术委员会2025年度关键技术研发计划"医学创新研究"项目(25Y12800600) （25Y12800600）
国家自然科学基金委员会青年项目(82305069) （82305069）
国家中医药管理局国家中医优势专科建设项目(肿瘤科-2024-510) Noncommunicable Chronic Diseases-National Science and Technol-ogy Major Project(No.2024ZD0521-402) （肿瘤科-2024-510）
Medical Innovation Research Pro-ject of the 2025 Key Technology Resea-rch and Development Program of the Science and Technology Commission of Shanghai Municipality(No.25Y12800-600) （No.25Y12800-600）
National Natural Science Found-ation of China(No.82305069) （No.82305069）
Natio-nal TCM Advantageous Specialty Cons-truction Project of the National Admi-nistration of Traditional Chinese Medi-cine(Oncology Department-2024-510) （Oncology Department-2024-510）
