中外医学研究2026，Vol.24Issue(10)：6-10,5.DOI:10.14033/j.cnki.cfmr.2026.10.002
0.1 mg GnRHa扳机在拮抗剂方案中对卵母细胞成熟及胚胎结局的影响
Ovulation Triggering with 0.1 mg GnRH Agonist in the Effect of Oocyte Maturation and Embryo Outcomes in Antagonist Protocols
摘要
Abstract
Objective:To compare the effects of 0.1 mg gonadotropin-releasing hormone agonist(GnRHa)and recombinant human chorionic gonadotropin(rhCG)triggering on oocyte maturation and embryonic outcomes in the antagonist protocol.Method:A retrospective cohort study was conducted to analyze 1 496 oocyte retrieval cycles from patients treated in the Reproductive Center of Kunming Maternal and Child Health Hospital from January 2019 to January 2024.According to different triggering method,they were divided into 2 groups:group A(triggering with 0.1 mg GnRHa)and group B(triggering with 250ug rhCG),who were matched the baseline data using 1∶1 propensity score matching(PSM).After the matching,the two groups of their baseline data,mature metaphase II(MII)oocyte rate,and key laboratory embryonic outcomes were compared between the two groups.Result:Before PSM matching,930 oocyte retrieval cycles were included in group A and 566 oocyte retrieval cycles were included in group B.Age,type of infertility,anti-Mullerian hormone level(AMH),basal follicle-stimulating hormone level(bFSH),basal luteinizing hormone level(bLH),and basal estrogen level(bE2)between the two groups were compared,and the difference was statistically significant(P<0.05),while there was no statistically significant difference in BMI between the two groups(P>0.05).After PSM matching,529 oocyte retrieval cycles were included in each group.There was no statistically significant difference in age,type of infertility,and BMI between the two groups(P>0.05),while there were statistically significant differences in AMH,bFSH,bLH,and bE2 levels(P<0.05).Compared with group B,there was no statistically significant difference in the MII egg rate in group A(P>0.05),but there was a higher double prokaryotic fertilization rate(2PN)and a higher rate of high-quality embryos at the cleavage stage,with statistically significant differences(P<0.05).Conclusion:In the antagonist protocol,0.1 mg GnRHa trigger yields similar MII rates compared to rhCG trigger.0.1 mg GnRHa alone may be considered in high ovarian response patients under antagonist protocol when freeze-all policy is applied.关键词
0.1 mg 促性腺激素释放激素激动剂/体外受精-胚胎移植/拮抗剂方案Key words
0.1mg GnRHa trigger/IVF-ET/GnRH antagonist protocol引用本文复制引用
杨蕴洁,路娜娜,黄荣芳,陈欣欣,姚颖杰,肖彭莹,寸金涛..0.1 mg GnRHa扳机在拮抗剂方案中对卵母细胞成熟及胚胎结局的影响[J].中外医学研究,2026,24(10):6-10,5.基金项目
云南省重大科技专项(202302AA310044) （202302AA310044）
昆明市卫生健康委课题(2023-05-03-001) （2023-05-03-001）
