中外医学研究2026，Vol.24Issue(10)：46-49,4.DOI:10.14033/j.cnki.cfmr.2026.10.010
糖化血红蛋白水平对稳定型心绞痛患者阿司匹林介导的血小板聚集率及不良心血管事件风险的影响
Impact of Glycated Hemoglobin Levels on Aspirin-Mediated Platelet Aggregation and Risk of Adverse Cardiovascular Events in Patients with Stable Angina Pectoris
摘要
Abstract
Objective:To investigate the impact of glycated hemoglobin(HbA1c)levels on aspirin-mediated platelet aggregation(PA)in patients with stable angina pectoris(SAP).Method:A retrospective analysis was conducted on 120 patients diagnosed with SAP in the hospital from January 2023 to June 2025 who were on long-term regular aspirin therapy(100 mg/d).According to their HbA1c levels,they were divided into a target group(HbA1c<6.5%,n=60)and a high-level group(HbA1c≥6.5%,n=60).The maximum platelet aggregation rate induced by arachidonic acid(AA,concentration 0.5 mmol/L)was measured using optical aggregometry.All patients were followed up for 6 months,and the occurrence of major adverse cardiovascular events(MACE,including acute myocardial infarction,rehospitalization for unstable angina,cardiac death,and ischemic stroke)was recorded in both groups.The relationship between HbA1c and platelet aggregation rate was explored.Result:Fasting blood glucose(FBG),low-density lipoprotein cholesterol(LDL-C),and HbA1c levels were significantly higher in the high-level group than in the target group(P<0.05).The AA-induced platelet aggregation rate was significantly higher in the high-level group compared with the target group(P<0.05).Pearson correlation analysis showed that HbA1c levels were significantly positively correlated with AA-induced platelet aggregation rate(r=0.528,P<0.001).During the 6-month follow-up period,the total incidence of MACE was significantly higher in the high-level group than in the target group(P<0.05).Multivariate Cox regression analysis indicated that elevated blood glucose,elevated HbA1c level and increased PA are independent risk factors for MACE in SAP patients,and the difference is statistically significant(P<0.05).Conclusion:High levels of glycated hemoglobin and FBG can significantly impair aspirin's inhibitory effect on platelet aggregation in patients with stable angina pectoris,increase the risk of"aspirin resistance",and are closely associated with a higher long-term risk of adverse cardiovascular events.关键词
糖化血红蛋白/稳定型心绞痛/阿司匹林/血小板聚集率/不良心血管事件Key words
Glycated hemoglobin/Stable angina pectoris/Aspirin/Platelet aggregation rate/Adverse cardiovascular events引用本文复制引用
张小娟,魏兆丽,丁玲岩,刘艳,李秀征..糖化血红蛋白水平对稳定型心绞痛患者阿司匹林介导的血小板聚集率及不良心血管事件风险的影响[J].中外医学研究,2026,24(10):46-49,4.基金项目
2022年滨州市中心医院科研计划项目(2022KJ009) （2022KJ009）
