中西医结合肝病杂志2026，Vol.36Issue(5)：533-538,6.DOI:10.3969/j.issn.1005-0264.2026.005.001
肌肉脂肪比例、体脂率与非肥胖型非酒精性脂肪性肝病的相关性
Correlation study of muscle-to-fat ratio and body fat percentage with non-obese NAFLD
摘要
Abstract
Objective:To investigate the correlation between muscle-to-fat ratio(MFR),body fat percentage(BFP)and non-obese non-alcoholic fatty liver disease(NAFLD)and their predictive value.Methods:Non-obese adults who participated in health checkups at Xiyuan Hospital of the China Academy of Traditional Chinese Medicine from 1 January 2021 to 31 December 2024 were enrolled in this study,and the baseline level was compared based on the presence or absence of NAFLD as a grouping basis;the correlation between the MFR and BFP and the prevalence of NAFLD in the non-obese population was analysed by using R 4.2.0 and EmpowerRCH 4.2;Interaction tests were performed based on gender,age,smoking history and previous disease history;the diagnostic predictive efficacy of MFR and BFP for NAFLD in the non-obese population was assessed and compared using receiver operating characteristic(ROC)curves.Results:A total of 1 045 non-obese samples were included in this study.After logistic regression correction for 20 confounders such as age,gender,smoking history,etc.,the likelihood of being diagnosed with NAFLD was reduced to 0.02 times for every 1-unit increase in MFR and 1.28 times for every 1-unit increase in BFP in non-obese individuals,respectively.Subgroup analyses showed that increasing MFR and decreasing BFP resulted in more benefit for women and the young and middle-aged group.ROC results showed that the Area under the curve(AUC)of MFR(0.780 7)was higher than that of BFP(0.7715),and there was a statistical difference between the two,with MFR having a superior diagnostic value,with an optimal threshold value of 1.121.Conclusion:MFR,BFP and the prevalence of NAFLD in the non-obese population showed a significant non-linear negative and positive correlation,respectively,and all of them have good diagnostic efficacy,and can be used for the early identification of NAFLD in the non-obese population.关键词
非酒精性脂肪性肝病/非肥胖人群/肌肉脂肪比例/体脂率Key words
non-alcoholic fatty liver disease/non-obesity/muscle fat ratio/body fat percentage分类
医药卫生引用本文复制引用
李纪新,邱林杰,任燕,王文茹,杨振宇,刘峰兆,邹姹姹,吴梓敬,张晋..肌肉脂肪比例、体脂率与非肥胖型非酒精性脂肪性肝病的相关性[J].中西医结合肝病杂志,2026,36(5):533-538,6.基金项目
国家重点研发计划子课题(No.2018YFC2000600),中国中医科学院科技创新工程(No.CI2021A03005) （No.2018YFC2000600）
