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首页|期刊导航|Green Synthesis and Catalysis|Modulating regioselectivity of CYP107J3-catalyzed isophorone hydroxylation by disrupting the hydrophobic balance of the substrate binding pocket

Modulating regioselectivity of CYP107J3-catalyzed isophorone hydroxylation by disrupting the hydrophobic balance of the substrate binding pocket

Meng Dai Xiaojuan Yu Xiaogang Peng Zhiyong Guo Huili Yu Aitao Li

Green Synthesis and Catalysis2026,Vol.7Issue(2):P.198-204,7.
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Green Synthesis and Catalysis2026,Vol.7Issue(2):P.198-204,7.DOI:10.1016/j.gresc.2024.05.007

Modulating regioselectivity of CYP107J3-catalyzed isophorone hydroxylation by disrupting the hydrophobic balance of the substrate binding pocket

Meng Dai 1Xiaojuan Yu 1Xiaogang Peng 1Zhiyong Guo 1Huili Yu 1Aitao Li1

作者信息

  • 1. State Key Laboratory of Biocatalysis and Enzyme Engineering,Hubei Key Laboratory of Industrial Biotechnology,School of Life Science,Hubei University,Wuhan 430062,China
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摘要

关键词

Isophorone hydroxylation/P450CYP107J3/Mechanism of regioselectivity/Multiscale simulation/Enzyme engineering

分类

化学化工

引用本文复制引用

Meng Dai,Xiaojuan Yu,Xiaogang Peng,Zhiyong Guo,Huili Yu,Aitao Li..Modulating regioselectivity of CYP107J3-catalyzed isophorone hydroxylation by disrupting the hydrophobic balance of the substrate binding pocket[J].Green Synthesis and Catalysis,2026,7(2):P.198-204,7.

基金项目

supported by the National Key Research and Development Program of China(No.2021YFC2102400) (No.2021YFC2102400)

the Key Science and Technology Innovation Project of Hubei Province(No.2021BAD001) (No.2021BAD001)

the Innovation Base for Introducing Talents of Discipline of Hubei Province(No.2019BJH021) (No.2019BJH021)

the Research Program of State Key Laboratory of Biocatalysis and Enzyme Engineering. ()

Green Synthesis and Catalysis

2666-5549

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